PGS Publication: PGP000177

Publication Information (EuropePMC)
Title The Challenge of Stratifying Obesity: Attempts in the Quebec Family Study.
PubMed ID 31649740(Europe PMC)
doi 10.3389/fgene.2019.00994
Publication Date Oct. 10, 2019
Journal Front Genet
Author(s) de Toro-Martín J, Guénard F, Bouchard C, Tremblay A, Pérusse L, Vohl MC.
Released in PGS Catalog: May 28, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000770
(PRS231)
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Body mass index (BMI) body mass index 231
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000770/ScoringFiles/PGS000770.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001987 PGS000770
(PRS231)
 PSS000992|
European Ancestry|
177 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity — — Odds Ratio (OR_Trend): 1.19 [1.06, 1.33] Age, sex, random effect (family relatedness) —
PPM001988 PGS000770
(PRS231)
 PSS000991|
European Ancestry|
141 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity — — Odds Ratio (OR_Trend): 1.12 [1.01, 1.25] Age, sex, random effect (family relatedness) —
PPM001989 PGS000770
(PRS231)
 PSS000992|
European Ancestry|
177 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity prevalence — AUROC: 0.661 — Bootstrapping (n=1000) —
PPM001990 PGS000770
(PRS231)
 PSS000991|
European Ancestry|
141 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity prevalence — AUROC: 0.619 — Bootstrapping (n=1000) —
PPM001991 PGS000770
(PRS231)
 PSS000992|
European Ancestry|
177 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity prevalence — AUROC: 0.127 [0.04, 0.22] — Age, sex, bootstrapping (n=1000) —
PPM001992 PGS000770
(PRS231)
 PSS000992|
European Ancestry|
177 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity prevalence — — Odds Ratio (OR, top 20% vs bottom 20%): 4.77 [1.54, 16.99] Age, sex, random effect (family relatedness) —
PPM001993 PGS000770
(PRS231)
 PSS000992|
European Ancestry|
177 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity prevalence — — Odds Ratio (OR, middle 40-60% vs bottom 20%): 3.46 [1.11, 12.31] Age, sex, random effect (family relatedness) —
PPM001994 PGS000770
(PRS231)
 PSS000991|
European Ancestry|
141 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Obesity prevalence — — Odds Ratio (OR, middle 60-80% vs bottom 20%): 3.79 [1.07, 15.86] Age, sex, random effect (family relatedness) —
PPM001995 PGS000770
(PRS231)
 PSS000992|
European Ancestry|
177 individuals
 PGP000177 |
de Toro-Martín J et al. Front Genet (2019)
 Reported Trait: Body mass index β: 0.33 — R²: 0.032 Sex, age —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000991 Cases were individuals defined as obese (BMI ≥ 30kg/m2) —
[
  • 39 cases
  • , 102 controls
]
,
48.23 % Male samples
 — European
(French-Canadian)		 — FAS —
PSS000992 Cases were individuals defined as obese (BMI ≥ 30kg/m2) —
[
  • 50 cases
  • , 127 controls
]
,
43.5 % Male samples
 — European
(French-Canadian)		 — QFS —