PGS Publication: PGP000189

Publication Information (EuropePMC)
Title Genetic risk scores do not improve asthma prediction in childhood.
PubMed ID 31145937(Europe PMC)
doi 10.1016/j.jaci.2019.05.017
Publication Date May 27, 2019
Journal J Allergy Clin Immunol
Author(s) Dijk FN, Folkersma C, Gruzieva O, Kumar A, Wijga AH, Gehring U, Kull I, Postma DS, Vonk JM, Melén E, Koppelman GH.
Released in PGS Catalog: June 11, 2021

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000799
(GRSw_TAGC)
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Asthma asthma 22
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000799/ScoringFiles/PGS000799.txt.gz
PGS000800
(GRSw_SHARE)
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Allergic disease allergy 133
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000800/ScoringFiles/PGS000800.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002081 PGS000800
(GRSw_SHARE)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 1.72 [1.21, 2.44]
PPM002083 PGS000800
(GRSw_SHARE)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 4.75
PPM002077 PGS000799
(GRSw_TAGC)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 1.23 [1.1, 1.38]
PPM002078 PGS000799
(GRSw_TAGC)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.66 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g)
PPM002079 PGS000799
(GRSw_TAGC)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years OR: 1.52 [1.19, 1.96] Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data.
PPM002080 PGS000799
(GRSw_TAGC)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.69 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g) Only 19 of the 22 SNP GRSw_TAGC were utilised. 3 SNPs were not used due to unavailability of data.
PPM002082 PGS000800
(GRSw_SHARE)
PSS001029|
European Ancestry|
1,858 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.65 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g)
PPM002084 PGS000800
(GRSw_SHARE)
PSS001028|
European Ancestry|
427 individuals
PGP000189 |
Dijk FN et al. J Allergy Clin Immunol (2019)
Reported Trait: Asthma ever, at age 8 years AUROC: 0.7 Familial risk score (factors: parental allergy, parental allergy to pets, parental inhaled medication, low parental education) , environmental risk score (factors: pets at home during pregnancy, smoking mother during pregnancy, older siblings living at home), perinatal risk score (factors: sex, low birth weight < 2500 g)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001028 Cases were children with asthma ever, at age 8 years. Cases were defined using an adjusted diagnosis of asthma ever at age 8 years based on (1) 1 or more attacks of wheeze in the last 12 months or (2) inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had at least 1 of these characteristics was categorized as having asthma.
[
  • 215 cases
  • , 212 controls
]
,
56.2 % Male samples
European
(Swedish)
BAMSE Possible sample overlap of up to 100% between this dataset and the datasets used to source variants for GRSw_TAGC.
PSS001029 Cases were children with asthma ever, at age 8 years, in which asthma was defined by the following characteristics: 1 or more attacks of wheeze in the last 12 months, 1 or more events of shortness of breath (dyspnea) in the last 12 months, or inhaled corticosteroids for respiratory or lung problems prescribed by a doctor in the last 12 months. A child who had 1 or more of these characteristics was categorized as having asthma.
[
  • 792 cases
  • , 1,066 controls
]
,
51.1 % Male samples
European PIAMA Possible sample overlap of up to 19% between this dataset and the datasets used to source variants for GRSw_TAGC.