| Publication Information (EuropePMC) | |
| Title | Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments. |
| PubMed ID | 33844929(Europe PMC) |
| doi | 10.1161/circgen.120.003201 |
| Publication Date | April 12, 2021 |
| Journal | Circ Genom Precis Med |
| Author(s) | Feitosa MF, Kuipers AL, Wojczynski MK, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA. |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | Ancestry distribution | Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000899 (PRS176_CHD) |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Coronary heart disease | coronary artery disease | 176 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000899/ScoringFiles/PGS000899.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM002641 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset | HR: 1.35 [1.26, 1.45] | — | — | Age, sex, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002642 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset | HR: 1.7 [1.41, 2.05] | — | — | Age, sex, study, PRS*sex, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002643 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset | HR: 1.75 [1.16, 2.65] | — | — | Age, sex, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, menopause, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002644 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset (males) | HR: 1.57 [1.28, 1.92] | — | — | Age, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002645 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset (males) | HR: 1.42 [1.3, 1.54] | — | — | Age, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002647 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset (females) | HR: 1.18 [1.04, 1.34] | — | — | Age, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002640 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset | HR: 1.6 [1.33, 1.92] | — | — | Age, sex, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
| PPM002646 | PGS000899 (PRS176_CHD) |
PSS001168| European Ancestry| 7,403 individuals |
PGP000232 | Feitosa MF et al. Circ Genom Precis Med (2021) |
Reported Trait: Prevalent coronary heart disease age-at-onset (females) | HR: 1.76 [1.16, 2.68] | — | — | Age, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking. | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS001168 | Cases were individulas with prevalent CHD was obtained by self-report of a coronary bypass, myocardial infarction, or any of the following: coronary angioplasty, balloon angioplasty, atherectomy, stent, percutaneous transluminal coronary angioplasty, or percutaneous coronary intervention. CHD information was similarly obtained in LLFS and FamHS; however, CHD was only validated by hospital records in FamHS. Age-at-onset was defined as the individual's age at the first report of CHD. | — | [ ,
46.25 % Male samples |
Mean = 60.6 years | European | — | FamHS, LLFS | — |