PGS Publication: PGP000232

Publication Information (EuropePMC)
Title Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments.
PubMed ID 33844929(Europe PMC)
doi 10.1161/circgen.120.003201
Publication Date April 12, 2021
Journal Circ Genom Precis Med
Author(s) Feitosa MF, Kuipers AL, Wojczynski MK, Wang L, Barinas-Mitchell E, Kulminski AM, Thyagarajan B, Lee JH, Perls T, Christensen K, Newman AB, Zmuda JM, Province MA.
Released in PGS Catalog: Sept. 17, 2021

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000899
(PRS176_CHD)
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Coronary heart disease coronary artery disease 176
-
http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000899/ScoringFiles/PGS000899.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002641 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset HR: 1.35 [1.26, 1.45] Age, sex, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002642 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset HR: 1.7 [1.41, 2.05] Age, sex, study, PRS*sex, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002643 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset HR: 1.75 [1.16, 2.65] Age, sex, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, menopause, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002644 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (males) HR: 1.57 [1.28, 1.92] Age, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002645 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (males) HR: 1.42 [1.3, 1.54] Age, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002647 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (females) HR: 1.18 [1.04, 1.34] Age, study, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002640 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset HR: 1.6 [1.33, 1.92] Age, sex, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.
PPM002646 PGS000899
(PRS176_CHD)
PSS001168|
European Ancestry|
7,403 individuals
PGP000232 |
Feitosa MF et al. Circ Genom Precis Med (2021)
Reported Trait: Prevalent coronary heart disease age-at-onset (females) HR: 1.76 [1.16, 2.68] Age, study, PRS*LLFS, PRS*FamnHS-High risk, type II diabetes, hypertension, high density lipoprotein cholesterol, low density lipoprotein cholesterol, waist circumference, current cigarette smoking, current alcohol drinking.

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001168 Cases were individulas with prevalent CHD was obtained by self-report of a coronary bypass, myocardial infarction, or any of the following: coronary angioplasty, balloon angioplasty, atherectomy, stent, percutaneous transluminal coronary angioplasty, or percutaneous coronary intervention. CHD information was similarly obtained in LLFS and FamHS; however, CHD was only validated by hospital records in FamHS. Age-at-onset was defined as the individual's age at the first report of CHD.
[
  • 950 cases
  • , 6,453 controls
]
,
46.25 % Male samples
Mean = 60.6 years European FamHS, LLFS