PGS Publication: PGP000278

Publication Information (EuropePMC)
Title Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.
PubMed ID 35016652(Europe PMC)
doi 10.1186/s12916-021-02198-9
Publication Date Jan. 12, 2022
Journal BMC Med
Author(s) Dashti HS, Miranda N, Cade BE, Huang T, Redline S, Karlson EW, Saxena R.
Released in PGS Catalog: Jan. 24, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
East Asian
South Asian
Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000278 |
Dashti HS et al. BMC Med (2022)
Body mass index (BMI) body mass index 97

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012804 PGS002251
European Ancestry|
33,511 individuals
PGP000278 |
Dashti HS et al. BMC Med (2022)
Reported Trait: Body mass index β: 0.83 [0.76, 0.9] age, sex, genotyping array, and 5 PCs of ancestry beta unit kg/m2

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009565 Clinically measured BMI 33,511 individuals,
46.9 % Male samples
Mean = 60.2 years
Sd = 16.9 years
European MGBB