PGS Publication: PGP000283

Publication Information (EuropePMC)
Title Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
PubMed ID 30224653(Europe PMC)
doi 10.1038/s41588-018-0205-x
Publication Date Sept. 17, 2018
Journal Nat Genet
Author(s) Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, Elosua R, Enroth S, Erzurumluoglu AM, Ferreira T, Frånberg M, Franco OH, Gandin I, Gasparini P, Giedraitis V, Gieger C, Girotto G, Goel A, Gow AJ, Gudnason V, Guo X, Gyllensten U, Hamsten A, Harris TB, Harris SE, Hartman CA, Havulinna AS, Hicks AA, Hofer E, Hofman A, Hottenga JJ, Huffman JE, Hwang SJ, Ingelsson E, James A, Jansen R, Jarvelin MR, Joehanes R, Johansson Å, Johnson AD, Joshi PK, Jousilahti P, Jukema JW, Jula A, Kähönen M, Kathiresan S, Keavney BD, Khaw KT, Knekt P, Knight J, Kolcic I, Kooner JS, Koskinen S, Kristiansson K, Kutalik Z, Laan M, Larson M, Launer LJ, Lehne B, Lehtimäki T, Liewald DCM, Lin L, Lind L, Lindgren CM, Liu Y, Loos RJF, Lopez LM, Lu Y, Lyytikäinen LP, Mahajan A, Mamasoula C, Marrugat J, Marten J, Milaneschi Y, Morgan A, Morris AP, Morrison AC, Munson PJ, Nalls MA, Nandakumar P, Nelson CP, Niiranen T, Nolte IM, Nutile T, Oldehinkel AJ, Oostra BA, O'Reilly PF, Org E, Padmanabhan S, Palmas W, Palotie A, Pattie A, Penninx BWJH, Perola M, Peters A, Polasek O, Pramstaller PP, Nguyen QT, Raitakari OT, Ren M, Rettig R, Rice K, Ridker PM, Ried JS, Riese H, Ripatti S, Robino A, Rose LM, Rotter JI, Rudan I, Ruggiero D, Saba Y, Sala CF, Salomaa V, Samani NJ, Sarin AP, Schmidt R, Schmidt H, Shrine N, Siscovick D, Smith AV, Snieder H, Sõber S, Sorice R, Starr JM, Stott DJ, Strachan DP, Strawbridge RJ, Sundström J, Swertz MA, Taylor KD, Teumer A, Tobin MD, Tomaszewski M, Toniolo D, Traglia M, Trompet S, Tuomilehto J, Tzourio C, Uitterlinden AG, Vaez A, van der Most PJ, van Duijn CM, Vergnaud AC, Verwoert GC, Vitart V, Völker U, Vollenweider P, Vuckovic D, Watkins H, Wild SH, Willemsen G, Wilson JF, Wright AF, Yao J, Zemunik T, Zhang W, Attia JR, Butterworth AS, Chasman DI, Conen D, Cucca F, Danesh J, Hayward C, Howson JMM, Laakso M, Lakatta EG, Langenberg C, Melander O, Mook-Kanamori DO, Palmer CNA, Risch L, Scott RA, Scott RJ, Sever P, Spector TD, van der Harst P, Wareham NJ, Zeggini E, Levy D, Munroe PB, Newton-Cheh C, Brown MJ, Metspalu A, Hung AM, O'Donnell CJ, Edwards TL, Psaty BM, Tzoulaki I, Barnes MR, Wain LV, Elliott P, Caulfield MJ, Million Veteran Program.
Released in PGS Catalog: Feb. 16, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002258
(GRS901_DBP)
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Diastolic blood pressure diastolic blood pressure 885
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002258/ScoringFiles/PGS002258.txt.gz
PGS002257
(GRS901_SBP)
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Systolic blood pressure systolic blood pressure 884
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002257/ScoringFiles/PGS002257.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012835 PGS002257
(GRS901_SBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Systolic blood pressure β: 2.06 [1.79, 2.32] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012836 PGS002257
(GRS901_SBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Diastolic blood pressure β: 1.64 [1.46, 1.81] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012837 PGS002257
(GRS901_SBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Pulse pressure β: 0.42 [0.25, 0.58] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012838 PGS002257
(GRS901_SBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Hypertension OR: 1.27 [1.23, 1.32] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012839 PGS002257
(GRS901_SBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Systolic blood pressure β: 2.38 [1.85, 2.9] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012840 PGS002257
(GRS901_SBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Diastolic blood pressure β: 1.39 [1.09, 1.7] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012841 PGS002257
(GRS901_SBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Pulse pressure β: 0.99 [0.65, 1.32] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012842 PGS002257
(GRS901_SBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Hypertension OR: 1.26 [1.2, 1.33] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012843 PGS002257
(GRS901_SBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Systolic blood pressure β: 2.58 [2.13, 3.03] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012844 PGS002257
(GRS901_SBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Diastolic blood pressure β: 1.49 [1.25, 1.74] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012845 PGS002257
(GRS901_SBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Pulse pressure β: 1.09 [0.8, 1.39] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012846 PGS002257
(GRS901_SBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Hypertension OR: 1.3 [1.24, 1.36] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012847 PGS002258
(GRS901_DBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Systolic blood pressure β: 2.06 [1.79, 2.32] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012848 PGS002258
(GRS901_DBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Diastolic blood pressure β: 1.64 [1.46, 1.81] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012849 PGS002258
(GRS901_DBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Pulse pressure β: 0.42 [0.25, 0.58] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012850 PGS002258
(GRS901_DBP)
PSS009574|
European Ancestry|
14,004 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Hypertension OR: 1.27 [1.23, 1.32] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012851 PGS002258
(GRS901_DBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Systolic blood pressure β: 2.38 [1.85, 2.9] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012852 PGS002258
(GRS901_DBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Diastolic blood pressure β: 1.39 [1.09, 1.7] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012853 PGS002258
(GRS901_DBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Pulse pressure β: 0.99 [0.65, 1.32] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012854 PGS002258
(GRS901_DBP)
PSS009575|
African Ancestry|
6,970 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Hypertension OR: 1.26 [1.2, 1.33] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012855 PGS002258
(GRS901_DBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Systolic blood pressure β: 2.58 [2.13, 3.03] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012856 PGS002258
(GRS901_DBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Diastolic blood pressure β: 1.49 [1.25, 1.74] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012857 PGS002258
(GRS901_DBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Pulse pressure β: 1.09 [0.8, 1.39] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP
PPM012858 PGS002258
(GRS901_DBP)
PSS009576|
South Asian Ancestry|
8,827 individuals
PGP000283 |
Evangelou E et al. Nat Genet (2018)
Reported Trait: Hypertension OR: 1.3 [1.24, 1.36] *Note performance is based on the average between GRS901_SBP and GRS_901_DBP

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009574 14,004 individuals European Airwave
PSS009575 6,970 individuals African unspecified UKB
PSS009576 8,827 individuals South Asian UKB