PGS Publication: PGP000286

Publication Information (EuropePMC)
Title Polygenic risk scores are associated with radiographic progression in patients with rheumatoid arthritis.
PubMed ID 35048562(Europe PMC)
doi 10.1002/art.42051
Publication Date Jan. 20, 2022
Journal Arthritis Rheumatol
Author(s) Honda S, Ikari K, Yano K, Terao C, Tanaka E, Harigai M, Kochi Y.
Released in PGS Catalog: March 16, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002260
(PRS_RA)
 PGP000286 |
Honda S et al. Arthritis Rheumatol (2022)
 Rheumatoid arthritis rheumatoid arthritis 43,784
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002260/ScoringFiles/PGS002260.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012870 PGS002260
(PRS_RA)
 PSS009586|
East Asian Ancestry|
740 individuals
 PGP000286 |
Honda S et al. Arthritis Rheumatol (2022)
 Reported Trait: Severe radiographic progression in patients with rheumatoid arthritis — — OR (top vs 2nd quintile): 1.87 [1.11, 3.15] — —
PPM012871 PGS002260
(PRS_RA)
 PSS009586|
East Asian Ancestry|
740 individuals
 PGP000286 |
Honda S et al. Arthritis Rheumatol (2022)
 Reported Trait: Severe radiographic progression in patients with rheumatoid arthritis (age of onset <40 years) — — OR (top vs 2nd quintile): 6.29 [1.85, 21.4] — —
PPM012872 PGS002260
(PRS_RA)
 PSS009586|
East Asian Ancestry|
740 individuals
 PGP000286 |
Honda S et al. Arthritis Rheumatol (2022)
 Reported Trait: Severe radiographic progression in patients with rheumatoid arthritis OR: 1.3 [1.13, 1.5] — — Age of onset, sex, ever-smoker, ACPAs positivity, rheumatoid factor positivity, BMI, periodontitis, use of methotrexate, use of bDMARD, HLA-DRB1 (Ser11) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009586 Severe progressive group as patients with the top quartile of SHS (more than 35 points) and the non-severe progressive group as the remaining patients. — 740 individuals,
14.4 % Male samples
 Mean = 48.5 years
Sd = 12.4 years		 East Asian
(Japanese)		 — IORRA —