PGS Publication: PGP000288

Publication Information (EuropePMC)
Title Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.
PubMed ID 35232999(Europe PMC)
doi 10.1038/s41598-022-07401-2
Publication Date March 1, 2022
Journal Sci Rep
Author(s) Garcia-Etxebarria K, Merino O, Gaite-Reguero A, Rodrigues PM, Herrarte A, Etxart A, Ellinghaus D, Alonso-Galan H, Franke A, Marigorta UM, Bujanda L, D'Amato M.
Released in PGS Catalog: March 16, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000017
(GPS_IBD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Inflammatory bowel disease inflammatory bowel disease 6,907,112
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000017/ScoringFiles/PGS000017.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012874 PGS000017
(GPS_IBD)
 PSS009588|
European Ancestry|
1,433 individuals
 PGP000288 |
Garcia-Etxebarria K et al. Sci Rep (2022)
|Ext.		 Reported Trait: Inflammatory Bowel Disease — AUROC: 0.69 [0.66, 0.72] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009588 — —
[
  • 498 cases
  • , 935 controls
]
 — European — BV —