PGS Publication: PGP000308

Publication Information (EuropePMC)
Title Polygenic risk for prostate cancer: Decreasing relative risk with age but little impact on absolute risk.
PubMed ID 35353984(Europe PMC)
doi 10.1016/j.ajhg.2022.03.008
Publication Date March 23, 2022
Journal Am J Hum Genet
Author(s) Schaid DJ, Sinnwell JP, Batzler A, McDonnell SK.
Released in PGS Catalog: April 13, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000662
(GRS.PCa.269)
 PGP000122 |
Conti DV et al. Nat Genet (2021)
 Prostate cancer prostate carcinoma 269
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012964 PGS000662
(GRS.PCa.269)
 PSS009633|
Multi-ancestry (including European)|
110,706 individuals
 PGP000308 |
Schaid DJ et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Prostate cancer — — Relative Risk (RR): 2.14 [2.09, 2.19] Ancestry, study —
PPM012965 PGS000662
(GRS.PCa.269)
 PSS009632|
European Ancestry|
91,623 individuals
 PGP000308 |
Schaid DJ et al. Am J Hum Genet (2022)
|Ext.		 Reported Trait: Prostate cancer — — Relative Risk (RR: 30 - 55 years old): 2.56 [2.47, 2.65]
Relative Risk (RR: 55 - 60 years old): 2.39
Relative Risk (RR: 60 - 65 years old): 2.24
Relative Risk (RR: 65 - 70 years old): 2.04
Relative risk per adjusted standard error (OPERA) per year of age: 0.00014
Relative Risk (RR: 70 - 88 years old): 1.86 [1.76, 1.98]		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009633 — —
[
  • 5,505 cases
  • , 5,370 controls
]
,
100.0 % Male samples
 — African American or Afro-Caribbean — BPC3, CGEMS, Ghana, PEGASUS GENEVA, ICPCG, ONCO
PSS009633 — —
[
  • 1,574 cases
  • , 1,483 controls
]
,
100.0 % Male samples
 — Asian unspecified — BPC3, CGEMS, Ghana, PEGASUS GENEVA, ICPCG, ONCO
PSS009633 — —
[
  • 54,564 cases
  • , 37,059 controls
]
,
100.0 % Male samples
 — European — BPC3, CGEMS, Ghana, PEGASUS GENEVA, ICPCG, ONCO
PSS009633 — —
[
  • 461 cases
  • , 452 controls
]
,
100.0 % Male samples
 — Sub-Saharan African
(Ghanaian)		 — BPC3, CGEMS, Ghana, PEGASUS GENEVA, ICPCG, ONCO
PSS009633 — —
[
  • 2,170 cases
  • , 2,068 controls
]
,
100.0 % Male samples
 — Hispanic or Latin American — BPC3, CGEMS, Ghana, PEGASUS GENEVA, ICPCG, ONCO
PSS009632 — —
[
  • 54,564 cases
  • , 37,059 controls
]
,
100.0 % Male samples
 — European — BPC3, CGEMS, Ghana, PEGASUS GENEVA, ICPCG, ONCO