PGS Publication: PGP000312

Publication Information (EuropePMC)
Title Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD.
PubMed ID 35293152(Europe PMC)
doi 10.1002/hep4.1932
Publication Date March 15, 2022
Journal Hepatol Commun
Author(s) Schnurr TM, Katz SF, Justesen JM, O'Sullivan JW, Saliba-Gustafsson P, Assimes TL, Carcamo-Orive I, Ahmed A, Ashley EA, Hansen T, Knowles JW.
Released in PGS Catalog: April 13, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002283
(GRS15_NAFLD)
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Nonalcoholic fatty liver disease non-alcoholic fatty liver disease 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002283/ScoringFiles/PGS002283.txt.gz
PGS002282
(GRS68_NAFLD)
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Nonalcoholic fatty liver disease non-alcoholic fatty liver disease 68
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002282/ScoringFiles/PGS002282.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012973 PGS002282
(GRS68_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels β: 0.13 (0.002) — — — —
PPM012974 PGS002283
(GRS15_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels β: 0.094 (0.002) — — — —
PPM012975 PGS002282
(GRS68_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels x physical activity interaction β: -0.28 (0.053) — — — —
PPM012976 PGS002282
(GRS68_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels x grip strength interaction β: -0.0067 (0.002) — — — —
PPM012977 PGS002282
(GRS68_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels x BMI interaction β: 0.037 (0.002) — — — —
PPM012978 PGS002283
(GRS15_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels x physical activity interaction β: -0.3 (0.053) — — — —
PPM012979 PGS002283
(GRS15_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels x grip strength interaction β: -0.011 (0.002) — — — —
PPM012980 PGS002283
(GRS15_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: ALT levels x BMI interaction β: 0.039 (0.002) — — — —
PPM012981 PGS002282
(GRS68_NAFLD)
 PSS009638|
European Ancestry|
25,716 individuals
 PGP000312 |
Schnurr TM et al. Hepatol Commun (2022)
 Reported Trait: Nonalcoholic fatty liver disease in those with normal weight and high level of physical activity — — Odds Ratio (OR, high vs. low GRS): 1.6 Sex, age, socioeconomic status, assessment center, genotyping array, and the first 10 principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009638 — — 25,716 individuals,
41.5 % Male samples
 Mean = 56.0 years
Sd = 7.7 years		 European — UKB —