PGS Publication: PGP000314

Publication Information (EuropePMC)
Title Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse.
PubMed ID 35739095(Europe PMC)
doi 10.1038/s41467-022-31188-5
Publication Date June 23, 2022
Journal Nat Commun
Author(s) Pujol-Gualdo N, Läll K, Lepamets M, Estonian Biobank Research Team, Rossi HR, Arffman RK, Piltonen TT, Mägi R, Laisk T.
Released in PGS Catalog: June 29, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002288
(PRS_POP)
 PGP000314 |
Pujol-Gualdo N et al. Nat Commun (2022)
 Pelvic organ prolapse pelvic organ prolapse 3,242,959
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002288/ScoringFiles/PGS002288.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012986 PGS002288
(PRS_POP)
 PSS009640|
European Ancestry|
98,656 individuals
 PGP000314 |
Pujol-Gualdo N et al. Nat Commun (2022)
 Reported Trait: Incident pelvic organ prolapse cases HR: 1.31 [1.25, 1.37] C-index: 0.592 — 10 PCs, and seven batche indicators —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009640 — —
[
  • 2,517 cases
  • , 96,139 controls
]
,
0.0 % Male samples
 — European — EB —