PGS Publication: PGP000316

Publication Information (EuropePMC)
Title Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife.
PubMed ID 35377426(Europe PMC)
doi 10.1001/jamanetworkopen.2022.5491
Publication Date April 1, 2022
Journal JAMA Netw Open
Author(s) Zimmerman SC, Brenowitz WD, Calmasini C, Ackley SF, Graff RE, Asiimwe SB, Staffaroni AM, Hoffmann TJ, Glymour MM.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002289
(GRS23_AD)
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Late-onset Alzheimer's disease late-onset Alzheimer's disease 23
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002289/ScoringFiles/PGS002289.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012991 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.3 — —
PPM012992 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of incorrect in person round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.4 — —
PPM012993 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) time to complete online round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 3.5 — —
PPM012994 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) time to complete in person round 2 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.5 — —
PPM012995 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Numeric memory (short-term memory and attention) no. of correct online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 8.8 — —
PPM012996 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. of correct in person x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.8 — —
PPM012997 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. attempted in person x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 5.7 — —
PPM012998 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) time to complete 10 substitutions online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 4.5 — —
PPM012999 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. of correct online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.4 — —
PPM013000 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Symbol digit substitution (processing speed) no. attempted online x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 2.0 — —
PPM012988 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of correct online round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 11.5 — —
PPM012989 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 1 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 7.9 — —
PPM012990 PGS002289
(GRS23_AD)
 PSS009642|
European Ancestry|
497,087 individuals
 PGP000316 |
Zimmerman SC et al. JAMA Netw Open (2022)
 Reported Trait: Pairs matching (short-term memory and attention) no. of correct in person round 2 x age interaction — — Difference in mean cognition per decacde increase in age per 1-SD higher GRS (%): 9.4 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009642 G30.1 Alzheimer’s disease with late onset — 497,087 individuals,
45.9 % Male samples
 Mean = 57.1 years
Sd = 7.9 years		 European — UKB —