PGS Publication: PGP000323

Publication Information (EuropePMC)
Title Associations of combined lifestyle and genetic risks with incident psoriasis: A prospective cohort study among UK Biobank participants of European ancestry.
PubMed ID 35427684(Europe PMC)
doi 10.1016/j.jaad.2022.04.006
Publication Date April 12, 2022
Journal J Am Acad Dermatol
Author(s) Shen M, Xiao Y, Jing D, Zhang G, Su J, Lin S, Chen X, Liu H.
Released in PGS Catalog: May 18, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
Psoriasis psoriasis 62

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013020 PGS002293
European Ancestry|
345,672 individuals
PGP000323 |
Shen M et al. J Am Acad Dermatol (2022)
Reported Trait: Incident psoriasis HR: 4.625 [2.92, 7.348] Odds Ratio (OR, poor lifestyle and high genetic risk): 4.625 [2.92, 7.348]
Population-attributable fraction of genetic risk: 0.13 [0.032, 0.218]
Age, sex, education, Townsend Index, and region, relatedness, number of alleles included in the polygenic risk score, and first 20 principal components of ancestry

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009651 Median = 10.88 years 345,672 individuals,
48.0 % Male samples
Mean = 56.53 years
Sd = 8.06 years
European UKB