PGS Publication: PGP000347

Publication Information (EuropePMC)
Title The age-dependent association of risk factors with pancreatic cancer.
PubMed ID 35398288(Europe PMC)
doi 10.1016/j.annonc.2022.03.276
Publication Date April 6, 2022
Journal Ann Oncol
Author(s) Yuan C, Kim J, Wang QL, Lee AA, Babic A, PanScan/PanC4 I-III Consortium, Amundadottir LT, Klein AP, Li D, McCullough ML, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Perez K, Ng K, Giovannucci EL, Stampfer MJ, Kraft P, Wolpin BM.
Released in PGS Catalog: Aug. 3, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS002740
(PRS22_PC)
 PGP000347 |
Yuan C et al. Ann Oncol (2022)
 Pancreatic cancer pancreatic carcinoma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002740/ScoringFiles/PGS002740.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014844 PGS002740
(PRS22_PC)
 PSS009913|
European Ancestry|
13,952 individuals
 PGP000347 |
Yuan C et al. Ann Oncol (2022)
 Reported Trait: Pancreatic cancer in those aged <= 60 years — — Odds ratio (OR, top vs bottom 10%): 6.91 [4.6, 10.4] — —
PPM014843 PGS002740
(PRS22_PC)
 PSS009913|
European Ancestry|
13,952 individuals
 PGP000347 |
Yuan C et al. Ann Oncol (2022)
 Reported Trait: Pancreatic cancer in those aged >70 years — — Odds ratio (OR, top vs bottom 10%): 4.12 [3.08, 5.52] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009913 — —
[
  • 5,107 cases
  • , 8,845 controls
]
 — European — PANSCAN —