PGS Publication: PGP000367

Publication Information (EuropePMC)
Title Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank.
PubMed ID 35978138(Europe PMC)
doi 10.1038/s41416-022-01918-z
Publication Date Aug. 18, 2022
Journal Br J Cancer
Author(s) Green HD, Merriel SWD, Oram RA, Ruth KS, Tyrrell J, Jones SE, Thirlwell C, Weedon MN, Bailey SER.
Released in PGS Catalog: Sept. 29, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000662
(GRS.PCa.269)
 PGP000122 |
Conti DV et al. Nat Genet (2021)
 Prostate cancer prostate carcinoma 269
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014985 PGS000662
(GRS.PCa.269)
 PSS009945|
European Ancestry|
6,715 individuals
 PGP000367 |
Green HD et al. Br J Cancer (2022)
|Ext.		 Reported Trait: Prostate cancer incidence in men with symptoms OR: 2.12 [1.86, 2.41] — — — —
PPM014986 PGS000662
(GRS.PCa.269)
 PSS009945|
European Ancestry|
6,715 individuals
 PGP000367 |
Green HD et al. Br J Cancer (2022)
|Ext.		 Reported Trait: Prostate cancer incidence in men with symptoms — AUROC: 0.772 [0.744, 0.8] — Age —
PPM014987 PGS000662
(GRS.PCa.269)
 PSS009945|
European Ancestry|
6,715 individuals
 PGP000367 |
Green HD et al. Br J Cancer (2022)
|Ext.		 Reported Trait: Prostate cancer incidence in men with symptoms — AUROC: 0.782 [0.755, 0.81] — Age, family history, symptom profile —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009945 Patients in the symptomatic cohort that were diagnosed with prostate cancer within 2 years of the index date were treated as cases. Patients with no record of a prostate cancer diagnosis within 2 years of the index date were considered controls —
[
  • 247 cases
  • , 6,468 controls
]
,
100.0 % Male samples
 — European — UKB —