PGS Publication: PGP000378

Publication Information (EuropePMC)
Title Coronary Artery Disease-Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study.
PubMed ID 34091660(Europe PMC)
doi 10.1093/cid/ciab521
Publication Date Nov. 1, 2021
Journal Clin Infect Dis
Author(s) Schoepf IC, Thorball CW, Ledergerber B, Engel T, Raffenberg M, Kootstra NA, Reiss P, Hasse B, Marzolini C, Thurnheer C, Seneghini M, Bernasconi E, Cavassini M, Buvelot H, Kouyos R, Günthard HF, Fellay J, Tarr PE, Swiss HIV Cohort Study.
Released in PGS Catalog: Oct. 19, 2022

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002795
(PRS_longetivity)
PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
Longevity (>90th survival percentile) longevity 4
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002795/ScoringFiles/PGS002795.txt.gz

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000018
(metaGRS_CAD)
PGP000007 |
Inouye M et al. J Am Coll Cardiol (2018)
Coronary artery disease coronary artery disease 1,745,179
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015502 PGS000018
(metaGRS_CAD)
PSS009965|
European Ancestry|
836 individuals
PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
|Ext.
Reported Trait: Coronary artery disease Odds Ratio (OR, fifth vs. first quintile): 3.17 [1.74, 5.79] Clinical risk factors
PPM015503 PGS002795
(PRS_longetivity)
PSS009965|
European Ancestry|
836 individuals
PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
Reported Trait: Coronary artery disease Odds Ratio (OR, fifth vs. first quintile): 1.61 [0.89, 2.91] Clinical risk factors
PPM015504 PGS000018
(metaGRS_CAD)
PSS009965|
European Ancestry|
836 individuals
PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
|Ext.
Reported Trait: Coronary artery disease Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] Clinical risk factors, PRS_longetivity Combined as metaPRS
PPM015505 PGS002795
(PRS_longetivity)
PSS009965|
European Ancestry|
836 individuals
PGP000378 |
Schoepf IC et al. Clin Infect Dis (2021)
Reported Trait: Coronary artery disease Odds Ratio (OR, fifth vs. first quintile): 3.67 [2.0, 6.73] Clinical risk factors, PGS000018 Combined as metaPRS

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009965 CAD events were defined according to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study and the MONICA Project of the World Health Organization, as reported elsewhere
[
  • 269 cases
  • , 567 controls
]
European SHCS