PGS Publication: PGP000394

Publication Information (EuropePMC)
Title Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout.
PubMed ID 36281732(Europe PMC)
doi 10.1002/art.42393
Publication Date Oct. 25, 2022
Journal Arthritis Rheumatol
Author(s) Sumpter NA, Takei R, Cadzow M, Topless RKG, Phipps-Green AJ, Murphy R, de Zoysa J, Watson H, Qasim M, Lupi AS, Abhishek A, Andrés M, Crișan TO, Doherty M, Jacobsson L, Janssen M, Jansen TL, Joosten LAB, Kapetanovic M, Lioté F, Matsuo H, McCarthy GM, Perez-Ruiz F, Riches P, Richette P, Roddy E, Stiburkova B, So A, Tausche AK, Torres RJ, Uhlig T, Major TJ, Stamp LK, Dalbeth N, Choi HK, Vazquez AI, Leask MP, Reynolds RJ, Merriman TR.
Released in PGS Catalog: Nov. 23, 2022

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS003329
(PRS19_gout)
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Gout gout 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003329/ScoringFiles/PGS003329.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016117 PGS003329
(PRS19_gout)
 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in men) β: -3.61 [-4.32, -2.9] — — 10 Global PCs —
PPM016120 PGS003329
(PRS19_gout)
 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in men) β: 1.15 [1.0, 1.31] — — 10 Global PCs —
PPM016123 PGS003329
(PRS19_gout)
 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in women) β: 0.07 [-2.32, 2.45] — — 10 Global PCs —
PPM016126 PGS003329
(PRS19_gout)
 PSS010039|
European Ancestry|
5,522 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in women) β: 0.68 [0.42, 1.1] — — 10 Global PCs —
PPM016119 PGS003329
(PRS19_gout)
 PSS010040|
Additional Diverse Ancestries|
869 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in men) β: -3.51 [-5.46, -1.57] — — 10 Global PCs + 10 Oceanian PCs —
PPM016121 PGS003329
(PRS19_gout)
 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in men) β: 2.6 [1.66, 4.06] — — 10 Global PCs + 10 Oceanian PCs —
PPM016122 PGS003329
(PRS19_gout)
 PSS010040|
Additional Diverse Ancestries|
869 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in men) β: 1.53 [1.07, 2.19] — — 10 Global PCs + 10 Oceanian PCs —
PPM016124 PGS003329
(PRS19_gout)
 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in women) β: 0.2 [-7.21, 7.62] — — 10 Global PCs + 10 Oceanian PCs —
PPM016125 PGS003329
(PRS19_gout)
 PSS010040|
Additional Diverse Ancestries|
869 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in women) β: -3.33 [-9.28, 2.62] — — 10 Global PCs + 10 Oceanian PCs —
PPM016127 PGS003329
(PRS19_gout)
 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Tophaceous Disease (in women) β: 1.45 [0.39, 5.36] — — 10 Global PCs + 10 Oceanian PCs —
PPM016118 PGS003329
(PRS19_gout)
 PSS010038|
Additional Diverse Ancestries|
1,386 individuals
 PGP000394 |
Sumpter NA et al. Arthritis Rheumatol (2022)
 Reported Trait: Age at onset of gout (in men) β: -6.35 [-8.91, -3.8] — — 10 Global PCs + 10 Oceanian PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010038 — —
[
  • 682 cases
  • , 704 controls
]
 — Oceanian Aotearoa NZ Maori and Cook Island Maori ancestry NR East Polynesian
PSS010039 — —
[
  • 4,016 cases
  • , 1,506 controls
]
 — European — CLEAR Australia and Aotearoa New Zealand cohort, GlobalGout, LASSO, CRYSTAL, LIGHT
PSS010040 — —
[
  • 490 cases
  • , 379 controls
]
 — Oceanian Samoan, Tongan, Niuean, Tokelauan and Pukapukan NR West Polynesian