PGS Publication: PGP000418

Publication Information (EuropePMC)
Title Polygenic risk in Type III hyperlipidaemia and risk of cardiovascular disease: An epidemiological study in UK Biobank and Oxford Biobank.
PubMed ID 36410544(Europe PMC)
doi 10.1016/j.ijcard.2022.11.024
Publication Date Nov. 19, 2022
Journal Int J Cardiol
Author(s) Pieri K, Trichia E, Neville MJ, Taylor H, Bennett D, Karpe F, Koivula RW.
Released in PGS Catalog: Jan. 19, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGP000418 |
Pieri K et al. Int J Cardiol (2022)
Triglyceride levels triglyceride measurement 108

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017030 PGS003401
European Ancestry|
460,037 individuals
PGP000418 |
Pieri K et al. Int J Cardiol (2022)
Reported Trait: Plasma triglyceride concentration β: 0.142 (0.000753) % change in TG (per SD PGS): 15.2 [15.0, 15.4]
PPM017031 PGS003401
European Ancestry|
6,952 individuals
PGP000418 |
Pieri K et al. Int J Cardiol (2022)
Reported Trait: Plasma triglyceride concentration β: 0.122 (0.00495) % change in TG (per SD PGS): 13.0 [12.0, 14.0]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010100 460,037 individuals,
45.7 % Male samples
European UKB
PSS010099 6,952 individuals,
43.5 % Male samples
European OBB