PGS Publication: PGP000419

Publication Information (EuropePMC)
Title The genetic risk of gestational diabetes in South Asian women.
PubMed ID 36412575(Europe PMC)
doi 10.7554/elife.81498
Publication Date Nov. 22, 2022
Journal Elife
Author(s) Lamri A, Limbachia J, Schulze KM, Desai D, Kelly B, de Souza RJ, Paré G, Lawlor DA, Wright J, Anand SS, Born in Bradford and START investigators.
Released in PGS Catalog: Jan. 19, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003402
(PRS_T2D)
 PGP000419 |
Lamri A et al. Elife (2022)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 6,838
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003402/ScoringFiles/PGS003402.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017036 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: Fasting glucose x BMI interaction β: 89.0 — — age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 —
PPM017037 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: Fasting glucose x Born in South Asia interaction β: 84.0 — — age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 —
PPM017038 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: Fasting glucose x Low diet quality interaction (only in START cohort) β: 0.141 [0.053, 0.228] — — age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 —
PPM017039 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: AUC glucose x BMI interaction β: 77.0 — — age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 —
PPM017040 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: GDM (IADPSG criteria) x BMI interaction OR: 0.0 — — age, BMI, education level, birth region (South Asia vs. other), parity, parental history of diabetes, and genetic PC axes 1-5 —
PPM017032 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: Fasting glucose β: 0.085 [0.067, 0.103] — — first five principal components (PCs) —
PPM017033 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: 2h postload glucose β: 0.207 [0.157, 0.257] — — first five principal components (PCs) —
PPM017034 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: AUC glucose β: 0.155 [0.125, 0.184] — — first five principal components (PCs) —
PPM017035 PGS003402
(PRS_T2D)
 PSS010101|
South Asian Ancestry|
3,712 individuals
 PGP000419 |
Lamri A et al. Elife (2022)
 Reported Trait: GDM (IADPSG criteria) OR: 1.45 [1.32, 1.6] — — first five principal components (PCs) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010101 — —
[
  • 514 cases
  • , 3,198 controls
]
,
0.0 % Male samples
 — South Asian — BiB, START 70% validation set from each cohort