PGS Publication: PGP000434

Publication Information (EuropePMC)
Title Clinical and genetic associations of deep learning-derived cardiac magnetic resonance-based left ventricular mass.
PubMed ID 36944631(Europe PMC)
doi 10.1038/s41467-023-37173-w
Publication Date March 21, 2023
Journal Nat Commun
Author(s) Khurshid S, Lazarte J, Pirruccello JP, Weng LC, Choi SH, Hall AW, Wang X, Friedman SF, Nauffal V, Biddinger KJ, Aragam KG, Batra P, Ho JE, Philippakis AA, Ellinor PT, Lubitz SA.
Released in PGS Catalog: March 24, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Multi-ancestry (including European)
Multi-ancestry (excluding European)
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000434 |
Khurshid S et al. Nat Commun (2023)
Left ventricular mass index (LVMI) left ventricular mass index 465

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017101 PGS003427
Multi-ancestry (including European)|
29,354 individuals
PGP000434 |
Khurshid S et al. Nat Commun (2023)
Reported Trait: incident implantable cardioverter-defibrillator implant HR: 1.05 age, sex, PC 1-5
PPM017100 PGS003427
Multi-ancestry (including European)|
443,326 individuals
PGP000434 |
Khurshid S et al. Nat Commun (2023)
Reported Trait: incident implantable cardioverter-defibrillator implant HR: 1.07 age, sex, PC 1-5

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010123 443,326 individuals,
45.5 % Male samples
Mean = 57.2 years European, NR 94% European UKB
PSS010124 29,354 individuals,
45.5 % Male samples
Mean = 55.4 years European, NR 85% European PHB