PGS Publication: PGP000443

Publication Information (EuropePMC)
Title Lifestyle, genetic risk and incidence of cancer: a prospective cohort study of 13 cancer types.
PubMed ID 36651198(Europe PMC)
doi 10.1093/ije/dyac238
Publication Date Jan. 18, 2023
Journal Int J Epidemiol
Author(s) Byrne S, Boyle T, Ahmed M, Lee SH, Benyamin B, Hyppönen E.
Released in PGS Catalog: March 3, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000071
(CC_Bladder)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Bladder cancer urinary bladder carcinoma 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000071/ScoringFiles/PGS000071.txt.gz
PGS000072
(CC_Breast)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Breast cancer breast carcinoma 187
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000072/ScoringFiles/PGS000072.txt.gz
PGS000074
(CC_Colorectal)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Colorectal cancer colorectal cancer 103
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000074/ScoringFiles/PGS000074.txt.gz
PGS000075
(CC_Endo)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Endometrial cancer endometrial carcinoma 9
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000075/ScoringFiles/PGS000075.txt.gz
PGS000076
(CC_Kidney)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Kidney cancer renal cell carcinoma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000076/ScoringFiles/PGS000076.txt.gz
PGS000077
(CC_LL)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Lymphocytic leukemia lymphoid leukemia 75
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000077/ScoringFiles/PGS000077.txt.gz
PGS000078
(CC_Lung)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Lung cancer lung carcinoma 109
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000078/ScoringFiles/PGS000078.txt.gz
PGS000079
(CC_Melanoma)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Melanoma melanoma 24
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000079/ScoringFiles/PGS000079.txt.gz
PGS000080
(CC_NHL)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Non-Hodgkin's lymphoma non-Hodgkins lymphoma 19
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000080/ScoringFiles/PGS000080.txt.gz
PGS000081
(CC_Oral)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Oral cavity and pharyngeal cancers oral cavity cancer,
pharynx cancer		 14
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000081/ScoringFiles/PGS000081.txt.gz
PGS000082
(CC_Ovary)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Ovarian cancer ovarian carcinoma 36
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000082/ScoringFiles/PGS000082.txt.gz
PGS000083
(CC_Pancreas)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Pancreatic cancer pancreatic carcinoma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000083/ScoringFiles/PGS000083.txt.gz
PGS000084
(CC_Prostate)
 PGP000050 |
Graff RE et al. Nat Commun (2021)
 Prostate cancer prostate carcinoma 161
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000084/ScoringFiles/PGS000084.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017164 PGS000074
(CC_Colorectal)
 PSS010144|
European Ancestry|
2,150 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Colorectal cancer HR: 1.36 [1.31, 1.42] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017165 PGS000072
(CC_Breast)
 PSS010142|
European Ancestry|
1,990 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Post-menopausal breast cancer HR: 1.26 [1.2, 1.32] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017166 PGS000078
(CC_Lung)
 PSS010146|
European Ancestry|
1,256 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Lung cancer HR: 1.26 [1.19, 1.33] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017167 PGS000079
(CC_Melanoma)
 PSS010153|
European Ancestry|
1,200 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Melanoma HR: 1.41 [1.33, 1.49] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017168 PGS000080
(CC_NHL)
 PSS010148|
European Ancestry|
721 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Non-Hodgkin's lymphoma HR: 1.19 [1.11, 1.28] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017169 PGS000076
(CC_Kidney)
 PSS010145|
European Ancestry|
547 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Kidney cancer HR: 1.14 [1.05, 1.24] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017170 PGS000075
(CC_Endo)
 PSS010152|
European Ancestry|
494 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Uterine cancer HR: 1.31 [1.2, 1.44] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017171 PGS000083
(CC_Pancreas)
 PSS010154|
European Ancestry|
451 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Pancreatic cancer HR: 1.51 [1.38, 1.66] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017172 PGS000071
(CC_Bladder)
 PSS010143|
European Ancestry|
424 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Bladder cancer HR: 1.21 [1.1, 1.33] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index —
PPM017173 PGS000081
(CC_Oral)
 PSS010150|
European Ancestry|
415 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Oral cavity and pharyngeal cancers HR: 1.03 [0.94, 1.14] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017174 PGS000082
(CC_Ovary)
 PSS010149|
European Ancestry|
315 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Ovarian cancer HR: 1.09 [0.97, 1.21] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —
PPM017175 PGS000077
(CC_LL)
 PSS010147|
European Ancestry|
246 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Lymphocytic leukemia HR: 1.5 [1.33, 1.69] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index —
PPM017163 PGS000084
(CC_Prostate)
 PSS010151|
European Ancestry|
4,476 individuals
 PGP000443 |
Byrne S et al. Int J Epidemiol (2023)
|Ext.		 Reported Trait: Prostate cancer HR: 1.36 [1.32, 1.4] — — age at baseline, sex (where relevant), assessment centre, 40 principal components of ancestries (PCs), Townsend Index, education, birth location, income, lifestyle index, additional cancer-specific covariates —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010142 — —
[
  • 225 cases
  • , 1,765 controls
]
,
0.0 % Male samples
 — European — UKB —
PSS010143 — —
[
  • 31 cases
  • , 393 controls
]
 — European — UKB —
PSS010144 — —
[
  • 180 cases
  • , 1,970 controls
]
 — European — UKB —
PSS010145 — —
[
  • 28 cases
  • , 519 controls
]
 — European — UKB —
PSS010146 — —
[
  • 104 cases
  • , 1,152 controls
]
 — European — UKB —
PSS010147 — —
[
  • 24 cases
  • , 222 controls
]
 — European — UKB —
PSS010148 — —
[
  • 61 cases
  • , 660 controls
]
 — European — UKB —
PSS010149 — —
[
  • 20 cases
  • , 295 controls
]
,
0.0 % Male samples
 — European — UKB —
PSS010150 — —
[
  • 26 cases
  • , 389 controls
]
 — European — UKB —
PSS010151 — —
[
  • 383 cases
  • , 4,093 controls
]
,
100.0 % Male samples
 — European — UKB —
PSS010152 — —
[
  • 35 cases
  • , 459 controls
]
,
0.0 % Male samples
 — European — UKB —
PSS010153 — —
[
  • 121 cases
  • , 1,079 controls
]
 — European — UKB —
PSS010154 — —
[
  • 57 cases
  • , 394 controls
]
 — European — UKB —