PGS Publication: PGP000449

Publication Information (EuropePMC)
Title Prediction of venous thromboembolism incidence in the general adult population using two published genetic risk scores.
PubMed ID 36716319(Europe PMC)
doi 10.1371/journal.pone.0280657
Publication Date Jan. 30, 2023
Journal PLoS One
Author(s) Folsom AR, Tang W, Hong CP, Rosamond WD, Lane JA, Cushman M, Pankratz N.
Released in PGS Catalog: March 24, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003456
(PRS273_VTE)
 PGP000449 |
Folsom AR et al. PLoS One (2023)
 Venous thromboembolism venous thromboembolism 273
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003456/ScoringFiles/PGS003456.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017257 PGS003456
(PRS273_VTE)
 PSS010177|
African Ancestry|
2,484 individuals
 PGP000449 |
Folsom AR et al. PLoS One (2023)
 Reported Trait: Total venous thromboembolism — — Hazard ratio (HR, high vs low tertile): 1.35 [0.81, 2.25] Adjusted for age, sex, principal components of ancestry, hormone replacement therapy (current, former, never for women, with men as referent category), education level (<high school, high school grad, >high school grad), household income (<$12,000, $12,000 to $24,999, $25,000 to $49,999, $50,000+, missing), height (continuous), weight (continuous), estimated glomerular filtration rate (continuous), diabetes (yes defined as >126 mg/dL, medication or physician diagnosis; no), smoking status (current, former, never), sports physical activity level (continuous), systolic blood pressure (continuous), antihypertensive medication use (yes, no) —
PPM017256 PGS003456
(PRS273_VTE)
 PSS010178|
European Ancestry|
8,808 individuals
 PGP000449 |
Folsom AR et al. PLoS One (2023)
 Reported Trait: Total venous thromboembolism — — Hazard ratio (HR, high vs low tertile): 2.52 [1.99, 3.2] Adjusted for age, sex, principal components of ancestry, hormone replacement therapy (current, former, never for women, with men as referent category), education level (<high school, high school grad, >high school grad), household income (<$12,000, $12,000 to $24,999, $25,000 to $49,999, $50,000+, missing), height (continuous), weight (continuous), estimated glomerular filtration rate (continuous), diabetes (yes defined as >126 mg/dL, medication or physician diagnosis; no), smoking status (current, former, never), sports physical activity level (continuous), systolic blood pressure (continuous), antihypertensive medication use (yes, no) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010178 — Median = 28.0 years 8,808 individuals — European — ARIC —
PSS010177 — Median = 28.0 years 2,484 individuals — African unspecified — ARIC —