PGS Preprint: PGP000461

Publication Information (EuropePMC)
Title Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD
doi 10.1101/2022.08.15.503980
Publication Date Aug. 15, 2022
Journal bioRxiv Preprint
Author(s) Dahl A, Thompson M, An U, Krebs M, Appadurai V, Border R, Bacanu S, Werge T, Flint J, Schork AJ, Sankararaman S, Kendler K, Cai N.
Released in PGS Catalog: April 12, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
Scoring File (FTP Link)
PGS003577
(AutoImpOnly.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 5,776,312
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003577/ScoringFiles/PGS003577.txt.gz
PGS003583
(MTAG.GPpsy.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 4,861,398
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003583/ScoringFiles/PGS003583.txt.gz
PGS003584
(SoftImpAll.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 5,776,312
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003584/ScoringFiles/PGS003584.txt.gz
PGS003585
(SoftImpOnly.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 5,776,312
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003585/ScoringFiles/PGS003585.txt.gz
PGS003579
(MTAG.AllDep.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 4,786,322
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003579/ScoringFiles/PGS003579.txt.gz
PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 4,786,322
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003580/ScoringFiles/PGS003580.txt.gz
PGS003581
(MTAG.Envs.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 4,861,398
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003581/ScoringFiles/PGS003581.txt.gz
PGS003576
(AutoImpAll.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 5,776,312
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003576/ScoringFiles/PGS003576.txt.gz
PGS003578
(MTAG.All.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 4,786,322
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003578/ScoringFiles/PGS003578.txt.gz
PGS003582
(MTAG.FamHist.LifetimeMDD)
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Major Depressive Disorder (Lifetime) major depressive disorder 4,861,398
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003582/ScoringFiles/PGS003582.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018180 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00898 PCs 1-10
PPM018181 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00726 PCs 1-10
PPM018182 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0044 PCs 1-10
PPM018183 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00842 PCs 1-10
PPM018184 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00537 PCs 1-10
PPM018185 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0207 PCs 1-10
PPM018187 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00508 PCs 1-20
PPM018188 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0071 PCs 1-20
PPM018189 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01722 PCs 1-20
PPM018190 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01492 PCs 1-10
PPM018191 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00395 PCs 1-10
PPM018192 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00491 PCs 1-10
PPM018193 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00837 PCs 1-10
PPM018194 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00546 PCs 1-10
PPM018196 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0121 PCs 1-10
PPM018197 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01598 PCs 1-20
PPM018198 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02548 PCs 1-20
PPM018199 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01284 PCs 1-20
PPM018200 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00727 PCs 1-10
PPM018201 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01033 PCs 1-10
PPM018202 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00658 PCs 1-10
PPM018204 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00491 PCs 1-10
PPM018205 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0241 PCs 1-10
PPM018206 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0181 PCs 1-10
PPM018207 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01668 PCs 1-20
PPM018208 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02062 PCs 1-20
PPM018209 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01847 PCs 1-20
PPM018210 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01013 PCs 1-10
PPM018211 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00938 PCs 1-10
PPM018212 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00505 PCs 1-10
PPM018213 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00482 PCs 1-10
PPM018214 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00405 PCs 1-10
PPM018215 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0182 PCs 1-10
PPM018216 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0141 PCs 1-10
PPM018217 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00953 PCs 1-20
PPM018219 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01454 PCs 1-20
PPM018220 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00551 PCs 1-10
PPM018221 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01906 PCs 1-10
PPM018222 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00363 PCs 1-10
PPM018223 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00962 PCs 1-10
PPM018224 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00957 PCs 1-10
PPM018226 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0145 PCs 1-10
PPM018227 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01562 PCs 1-20
PPM018228 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01608 PCs 1-20
PPM018229 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01652 PCs 1-20
PPM018230 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00169 PCs 1-10
PPM018231 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00598 PCs 1-10
PPM018232 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00234 PCs 1-10
PPM018233 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00581 PCs 1-10
PPM018235 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0182 PCs 1-10
PPM018236 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0147 PCs 1-10
PPM018237 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01186 PCs 1-20
PPM018238 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01336 PCs 1-20
PPM018239 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01224 PCs 1-20
PPM018240 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00305 PCs 1-10
PPM018241 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01232 PCs 1-10
PPM018242 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00193 PCs 1-10
PPM018244 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00819 PCs 1-10
PPM018245 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0104 PCs 1-10
PPM018246 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0064 PCs 1-10
PPM018247 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00441 PCs 1-20
PPM018248 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01656 PCs 1-20
PPM018249 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01091 PCs 1-20
PPM018250 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00955 PCs 1-10
PPM018251 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02257 PCs 1-10
PPM018253 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0115 PCs 1-10
PPM018254 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01013 PCs 1-10
PPM018255 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0204 PCs 1-10
PPM018256 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0155 PCs 1-10
PPM018257 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01754 PCs 1-20
PPM018258 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01951 PCs 1-20
PPM018259 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01771 PCs 1-20
PPM018260 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00134 PCs 1-10
PPM018262 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00539 PCs 1-10
PPM018263 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01207 PCs 1-10
PPM018264 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00827 PCs 1-10
PPM018265 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0254 PCs 1-10
PPM018266 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0207 PCs 1-10
PPM018267 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02512 PCs 1-20
PPM018268 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01435 PCs 1-20
PPM018269 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02075 PCs 1-20
PPM018271 PGS003578
(MTAG.All.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01 PCs 1-10
PPM018272 PGS003578
(MTAG.All.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0048 PCs 1-10
PPM018273 PGS003578
(MTAG.All.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01087 PCs 1-10
PPM018274 PGS003578
(MTAG.All.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00943 PCs 1-10
PPM018275 PGS003578
(MTAG.All.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0257 PCs 1-10
PPM018276 PGS003578
(MTAG.All.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0199 PCs 1-10
PPM018277 PGS003578
(MTAG.All.LifetimeMDD)
PSS010951|
African Ancestry|
687 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02024 PCs 1-20
PPM018278 PGS003578
(MTAG.All.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.02182 PCs 1-20
PPM018203 PGS003576
(AutoImpAll.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01563 PCs 1-10
PPM018186 PGS003584
(SoftImpAll.LifetimeMDD)
PSS010955|
European Ancestry|
23,351 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.016 PCs 1-10
PPM018195 PGS003585
(SoftImpOnly.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0176 PCs 1-10
PPM018218 PGS003577
(AutoImpOnly.LifetimeMDD)
PSS010952|
Additional Asian Ancestries|
334 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01605 PCs 1-20
PPM018225 PGS003583
(MTAG.GPpsy.LifetimeMDD)
PSS010954|
European Ancestry|
42,250 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0198 PCs 1-10
PPM018234 PGS003581
(MTAG.Envs.LifetimeMDD)
PSS010950|
East Asian Ancestry|
10,502 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00336 PCs 1-10
PPM018243 PGS003582
(MTAG.FamHist.LifetimeMDD)
PSS010949|
Hispanic or Latin American Ancestry|
2,454 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00709 PCs 1-10
PPM018252 PGS003579
(MTAG.AllDep.LifetimeMDD)
PSS010948|
European Ancestry|
14,388 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.00435 PCs 1-10
PPM018261 PGS003580
(MTAG.AllDepEnvs.LifetimeMDD)
PSS010947|
Additional Asian Ancestries|
1,996 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0156 PCs 1-10
PPM018270 PGS003578
(MTAG.All.LifetimeMDD)
PSS010946|
African Ancestry|
1,158 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.0038 PCs 1-10
PPM018279 PGS003578
(MTAG.All.LifetimeMDD)
PSS010953|
European Ancestry|
10,193 individuals
PGP000461 |
Dahl A et al. bioRxiv (2022)
|Pre
Reported Trait: Major depressive disorder : 0.01995 PCs 1-20

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010946
[
  • 90 cases
  • , 1,068 controls
]
Range = [18.0, 86.0] years African unspecified
(Black)
UCLA
PSS010947
[
  • 91 cases
  • , 1,905 controls
]
Range = [18.0, 86.0] years Asian unspecified
(Asian)
UCLA
PSS010948
[
  • 1,428 cases
  • , 12,960 controls
]
Range = [18.0, 86.0] years European UCLA
PSS010949
[
  • 199 cases
  • , 2,255 controls
]
Range = [18.0, 86.0] years Hispanic or Latin American
(Latino)
UCLA
PSS010950
[
  • 5,282 cases
  • , 5,220 controls
]
Range = [30.0, 60.0] years East Asian
(Han Chinese)
CONVERGE
PSS010951
[
  • 122 cases
  • , 565 controls
]
Range = [37.0, 74.0] years African unspecified
(African)
UKB
PSS010952
[
  • 62 cases
  • , 272 controls
]
Range = [37.0, 74.0] years Asian unspecified
(Asian)
UKB
PSS010953
[
  • 2,741 cases
  • , 7,452 controls
]
Range = [37.0, 74.0] years European UKB
PSS010954
[
  • 18,879 cases
  • , 23,371 controls
]
Range = [8.0, 32.0] years European
(Danish)
iPSYCH
PSS010955
[
  • 8,188 cases
  • , 15,163 controls
]
Range = [8.0, 35.0] years European
(Danish)
iPSYCH