PGS Preprint: PGP000463

Publication Information (EuropePMC)
Title Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy
doi 10.1101/2021.08.17.21261668
Publication Date Aug. 20, 2021
Journal medRxiv Preprint
Author(s) Kleeman SO, Demestichas B, Mourikis N, Loiero D, Ferrer M, Bankier S, Riazat-Kesh YJ, Lee H, Chantzichristos D, Regan C, Preall J, Sinha S, Rosin N, Yipp B, de Almeida LG, Biernaskie J, Dufour A, Tober-Lau P, Ruusalepp A, Bjorkegren JLM, Ralser M, Kurth F, Demechev V, Heywood T, Gao Q, Johannsson G, Koelzer VH, Walker BR, Meyer HV, Janowitz T.
Released in PGS Catalog: April 28, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003589
(UKB_cycproduction_EUR)
 PGP000463 |
Kleeman SO et al. medRxiv (2021)
|Pre		 Cystatin C production cystatin C measurement 1,031,527
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003589/ScoringFiles/PGS003589.txt.gz
PGS003590
(UKB_cycproduction_EUR_exome)
 PGP000463 |
Kleeman SO et al. medRxiv (2021)
|Pre		 Cystatin C production cystatin C measurement 352,549
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003590/ScoringFiles/PGS003590.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018283 PGS003589
(UKB_cycproduction_EUR)
 PSS010957|
European Ancestry|
50,000 individuals
 PGP000463 |
Kleeman SO et al. medRxiv (2021)
|Pre		 Reported Trait: Cystatin C production — — R²: 0.08 Age, sex, PC1-4, recruitment center, genotyping array —
PPM018284 PGS003590
(UKB_cycproduction_EUR_exome)
 PSS010957|
European Ancestry|
50,000 individuals
 PGP000463 |
Kleeman SO et al. medRxiv (2021)
|Pre		 Reported Trait: Cystatin C production — — R²: 0.04 Age, sex, PC1-4, recruitment center, genotyping array —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010957 — — 50,000 individuals — European — UKB —