PGS Publication: PGP000474

Publication Information (EuropePMC)
Title Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility.
PubMed ID 36826816(Europe PMC)
doi 10.1001/jamanetworkopen.2023.0666
Publication Date Feb. 1, 2023
Journal JAMA Netw Open
Author(s) Hurwitz LM, Webb PM, Jordan SJ, Doherty JA, Harris HR, Goodman MT, Shvetsov YB, Modugno F, Moysich KB, Schildkraut JM, Berchuck A, Anton-Culver H, Ziogas A, Menon U, Ramus SJ, Wu AH, Pearce CL, Wentzensen N, Tworoger SS, Pharoah PDP, Trabert B.
Released in PGS Catalog: June 22, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003754
(PRS22_OCstepwise)
 PGP000474 |
Hurwitz LM et al. JAMA Netw Open (2023)
 Nonmucinous Epithelial Ovarian Cancer ovarian carcinoma 22
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003754/ScoringFiles/PGS003754.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018518 PGS003754
(PRS22_OCstepwise)
 PSS011005|
Multi-ancestry (including European)|
11,135 individuals
 PGP000474 |
Hurwitz LM et al. JAMA Netw Open (2023)
 Reported Trait: Nonmucinous Epithelial Ovarian Cancer x aspirin use interaction — — Odds ratio (OR, <median): 0.85 [0.7, 1.02]
Odds ratio (OR, >=median): 0.86 [0.74, 1.01]		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011005 — —
[
  • 122 cases
  • , 218 controls
]
 — African American or Afro-Caribbean
(Black)		 — OCAC —
PSS011005 — —
[
  • 3,995 cases
  • , 5,851 controls
]
 — European — OCAC —
PSS011005 — —
[
  • 359 cases
  • , 590 controls
]
 — Not reported — OCAC —