PGS Publication: PGP000493

Publication Information (EuropePMC)
Title Age and Genetic Risk Score and Rates of Blood Lipid Changes in China.
PubMed ID 36988954(Europe PMC)
doi 10.1001/jamanetworkopen.2023.5565
Publication Date March 1, 2023
Journal JAMA Netw Open
Author(s) Li J, Liu M, Liu F, Chen S, Huang K, Cao J, Shen C, Liu X, Yu L, Zhao Y, Zhang H, Gu S, Zhao L, Li Y, Hu D, Huang J, Gu D, Lu X.
Released in PGS Catalog: Sept. 1, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS003855
(PRS44_LDL)
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 LDL cholesterol low density lipoprotein cholesterol measurement 44
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003855/ScoringFiles/PGS003855.txt.gz
PGS003856
(PRS59_HDL)
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 HDL cholesterol high density lipoprotein cholesterol measurement 59
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003856/ScoringFiles/PGS003856.txt.gz
PGS003853
(PRS60_TC)
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Total cholesterol total cholesterol measurement 60
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003853/ScoringFiles/PGS003853.txt.gz
PGS003854
(PRS40_TG)
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Triglycerides triglyceride measurement 40
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003854/ScoringFiles/PGS003854.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018685 PGS003853
(PRS60_TC)
 PSS011066|
East Asian Ancestry|
37,317 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of total cholesterol — — p-value (inferior to): 0.001 — —
PPM018686 PGS003854
(PRS40_TG)
 PSS011066|
East Asian Ancestry|
37,317 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of triglycerides — — p-value (inferior to): 0.001 — —
PPM018687 PGS003855
(PRS44_LDL)
 PSS011066|
East Asian Ancestry|
37,317 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of LDL cholesterol — — p-value (inferior to): 0.001 — —
PPM018688 PGS003856
(PRS59_HDL)
 PSS011066|
East Asian Ancestry|
37,317 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of HDL cholesterol — — p-value (inferior to): 0.001 — —
PPM018689 PGS003853
(PRS60_TC)
 PSS011068|
East Asian Ancestry|
15,664 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of total cholesterol — — p-value (inferior to): 0.001 — —
PPM018690 PGS003854
(PRS40_TG)
 PSS011068|
East Asian Ancestry|
15,664 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of triglycerides — — p-value (inferior to): 0.001 — —
PPM018691 PGS003855
(PRS44_LDL)
 PSS011068|
East Asian Ancestry|
15,664 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of LDL cholesterol — — p-value (inferior to): 0.001 — —
PPM018692 PGS003856
(PRS59_HDL)
 PSS011068|
East Asian Ancestry|
15,664 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of HDL cholesterol — — p-value (inferior to): 0.001 — —
PPM018693 PGS003853
(PRS60_TC)
 PSS011067|
East Asian Ancestry|
21,653 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of total cholesterol — — p-value (inferior to): 0.001 — —
PPM018694 PGS003854
(PRS40_TG)
 PSS011067|
East Asian Ancestry|
21,653 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of triglycerides — — p-value (inferior to): 0.001 — —
PPM018695 PGS003855
(PRS44_LDL)
 PSS011067|
East Asian Ancestry|
21,653 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of LDL cholesterol — — p-value (inferior to): 0.001 — —
PPM018696 PGS003856
(PRS59_HDL)
 PSS011067|
East Asian Ancestry|
21,653 individuals
 PGP000493 |
Li J et al. JAMA Netw Open (2023)
 Reported Trait: Estimated annual change of HDL cholesterol — — p-value (inferior to): 0.001 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011066 — — 37,317 individuals,
41.98 % Male samples
 Mean = 51.37 years
Sd = 10.82 years		 East Asian — InterASIA China MUCA, CIMIC
PSS011067 — — 21,653 individuals,
41.98 % Male samples
 Mean = 51.22 years
Sd = 10.78 years		 East Asian — InterASIA China MUCA, CIMIC
PSS011068 — — 15,664 individuals,
41.98 % Male samples
 Mean = 51.57 years
Sd = 10.87 years		 East Asian — InterASIA China MUCA, CIMIC