PGS Publication: PGP000499

Publication Information (EuropePMC)
Title Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population.
PubMed ID 37076872(Europe PMC)
doi 10.1186/s12916-023-02844-4
Publication Date April 19, 2023
Journal BMC Med
Author(s) Zhang Z, Li H, Weng H, Zhou G, Chen H, Yang G, Zhang P, Zhang X, Ji Y, Ying K, Liu B, Xu Q, Tang Y, Zhu G, Liu Z, Xia S, Yang X, Dong L, Zhu L, Zeng M, Yuan Y, Yang Y, Zhang N, Xu X, Pang W, Zhang M, Zhang Y, Zhen K, Wang D, Lei J, Wu S, Shu S, Zhang Y, Zhang S, Gao Q, Huang Q, Deng C, Fu X, Chen G, Duan W, Wan J, Xie W, Zhang P, Wang S, Yang P, Zuo X, Zhai Z, Wang C, China pUlmonary Thromboembolism REgistry Study (CURES) investigators.
Released in PGS Catalog: Sept. 1, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
East Asian
South Asian
Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGP000499 |
Zhang Z et al. BMC Med (2023)
Pulmonary embolism pulmonary embolism 288

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018751 PGS003861
East Asian Ancestry|
9,456 individuals
PGP000499 |
Zhang Z et al. BMC Med (2023)
Reported Trait: Pulmonary embolism AUROC: 0.765 Odds ratio (OR, 30-70th quantile vs <90th quantile): 5.08 [4.109, 6.282]

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 646 cases
  • , 8,810 controls
46.34 % Male samples
East Asian
(Han Chinese)