PGS Publication: PGP000504

Publication Information (EuropePMC)
Title A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.
PubMed ID 36959271(Europe PMC)
doi 10.1038/s41598-023-31496-w
Publication Date March 23, 2023
Journal Sci Rep
Author(s) Duschek E, Forer L, Schönherr S, Gieger C, Peters A, Kronenberg F, Grallert H, Lamina C.
Released in PGS Catalog: Oct. 17, 2023

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000014
(GPS_T2D)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 6,917,436
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000014/ScoringFiles/PGS000014.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019100 PGS000014
(GPS_T2D)
 PSS011181|
Ancestry Not Reported|
3,071 individuals
 PGP000504 |
Duschek E et al. Sci Rep (2023)
|Ext.		 Reported Trait: Incident type 2 diabetes — AUROC: 0.613 [0.565, 0.657] — — —
PPM019098 PGS000014
(GPS_T2D)
 PSS011181|
Ancestry Not Reported|
3,071 individuals
 PGP000504 |
Duschek E et al. Sci Rep (2023)
|Ext.		 Reported Trait: Incident type 2 diabetes OR: 1.67 [1.37, 2.03] — — Age, Sex, BMI, Physical activity, FamRS —
PPM019099 PGS000014
(GPS_T2D)
 PSS011181|
Ancestry Not Reported|
3,071 individuals
 PGP000504 |
Duschek E et al. Sci Rep (2023)
|Ext.		 Reported Trait: Prevelant type 2 diabetes — AUROC: 0.869 [0.842, 0.896] — — —
PPM019097 PGS000014
(GPS_T2D)
 PSS011181|
Ancestry Not Reported|
3,071 individuals
 PGP000504 |
Duschek E et al. Sci Rep (2023)
|Ext.		 Reported Trait: Prevelant type 2 diabetes OR: 6.21 [5.06, 7.74] — — Age, Sex, BMI, Physical activity, FamRS —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011181 — — 3,071 individuals,
48.8 % Male samples
 Mean = 57.4 years
Sd = 12.88 years		 Not reported — KORA —