PGS Publication: PGP000523

Publication Information (EuropePMC)
Title Association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes.
PubMed ID 37201819(Europe PMC)
doi 10.1016/j.scitotenv.2023.164253
Publication Date May 16, 2023
Journal Sci Total Environ
Author(s) Lin J, Yang H, Zhang Y, Zhou L, Chen Y, Xu W, Wang Y.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004223
(PRS139_T2D)
 PGP000523 |
Lin J et al. Sci Total Environ (2023)
 Type 2 diabetes type 2 diabetes mellitus 139
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004223/ScoringFiles/PGS004223.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020158 PGS004223
(PRS139_T2D)
 PSS011299|
European Ancestry|
395,809 individuals
 PGP000523 |
Lin J et al. Sci Total Environ (2023)
 Reported Trait: Incident type 2 diabetes HR: 1.5 [1.48, 1.52] — — age, gender, education, Townsend deprivation index, smoking status, alcohol consumption, body mass index, total physical activity, dietary pattern, vitamin D supplement, use of sun/UV protection, PM2.5, hypertension, cardiovascular disease, antihypertensive medications use, cholesterol-lowering medications use, and average outdoor light time —
PPM020159 PGS004223
(PRS139_T2D)
 PSS011299|
European Ancestry|
395,809 individuals
 PGP000523 |
Lin J et al. Sci Total Environ (2023)
 Reported Trait: Incident type 2 diabetes with outdoor light time in summer — — Hazard ratio (HR, outdoor light time in summer >3h/day and PRS in top tertile vs. outdoor light time in summer <2-3 h/day and PRS in bottom tertile): 2.53 [2.39, 2.69] Hb1Ac concentrations at baseline —
PPM020160 PGS004223
(PRS139_T2D)
 PSS011299|
European Ancestry|
395,809 individuals
 PGP000523 |
Lin J et al. Sci Total Environ (2023)
 Reported Trait: Incident type 2 diabetes with outdoor light time in winter — — Hazard ratio (HR, outdoor light time in winter >2 h/day and PRS in top tertile vs. outdoor light time in winter <1-2 h/day and PRS in bottom tertile): 2.56 [2.42, 2.71] Hb1Ac concentrations at baseline —
PPM020161 PGS004223
(PRS139_T2D)
 PSS011299|
European Ancestry|
395,809 individuals
 PGP000523 |
Lin J et al. Sci Total Environ (2023)
 Reported Trait: Incident type 2 diabetes with outdoor light time on average — — Hazard ratio (HR, outdoor light time on average >2.5 h/day and PRS in top tertile vs. outdoor light time on average 1.5-2.5 h/day and PRS in bottom tertile): 2.52 [2.37, 2.67] Hb1Ac concentrations at baseline —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011299 T2D ICD-10 code E11 Median = 12.55 years
IQR = [11.72, 13.27] years		 395,809 individuals,
45.8 % Male samples
 Mean = 56.7 years
Sd = 8.0 years		 European — UKB —