PGS Publication: PGP000535

Publication Information (EuropePMC)
Title Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus.
PubMed ID 33350037(Europe PMC)
doi 10.1002/jgm.3305
Publication Date Jan. 22, 2021
Journal J Gene Med
Author(s) Cheng CF, Lin YJ, Lin MC, Liang WM, Chen CC, Chen CH, Wu JY, Lin TH, Liao CC, Huang SM, Hsieh AR, Tsai FJ.
Released in PGS Catalog: Dec. 15, 2023

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004238
(wGRS35)
 PGP000535 |
Cheng CF et al. J Gene Med (2021)
 Cardiovascular disease cardiovascular disease 35
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004238/ScoringFiles/PGS004238.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020271 PGS004238
(wGRS35)
 PSS011317|
East Asian Ancestry|
385 individuals
 PGP000535 |
Cheng CF et al. J Gene Med (2021)
 Reported Trait: Cardiovascular disease in patients with type II diabetes Mellitus — AUROC: 0.666 [0.595, 0.737] — — —
PPM020272 PGS004238
(wGRS35)
 PSS011317|
East Asian Ancestry|
385 individuals
 PGP000535 |
Cheng CF et al. J Gene Med (2021)
 Reported Trait: Cardiovascular disease in patients with type II diabetes Mellitus — AUROC: 0.78 [0.717, 0.843] — Age, gender, body mass index —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011317 The cardiovascular disease patients (cases) were diagnosed by a licensed medical doctor based on events (e.g. angina, myocardial infarction, stroke) and/or interventions (e.g. coronary angioplasty/stenting, coronary artery bypass grafting, carotid endarterectomy). —
[
  • 68 cases
  • , 317 controls
]
,
51.42 % Male samples
 — East Asian
(Han Chinese)		 — NR —