PGS Publication: PGP000558

Publication Information (EuropePMC)
Title A Polygenic Risk Score for Predicting Racial and Genetic Susceptibility to Prurigo Nodularis.
PubMed ID 37245863(Europe PMC)
doi 10.1016/j.jid.2023.04.033
Publication Date May 26, 2023
Journal J Invest Dermatol
Author(s) Vasavda C, Wan G, Szeto MD, Marani M, Sutaria N, Rajeh A, Lu C, Lee KK, Nguyen NTT, Adawi W, Deng J, Parthasarathy V, Bordeaux ZA, Taylor MT, Alphonse MP, Kwatra MM, Kang S, Semenov YR, Gusev A, Kwatra SG.
Released in PGS Catalog: Jan. 11, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000558 |
Vasavda C et al. J Invest Dermatol (2023)
Prurigo nodularis prurigo nodularis 6,314

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020437 PGS004324
European Ancestry|
405,582 individuals
PGP000558 |
Vasavda C et al. J Invest Dermatol (2023)
Reported Trait: Prurigo nodularis OR: 1.27 race, age, and sex

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
  • 73 cases
  • , 405,509 controls
European UKB