PGS Publication: PGP000579

Publication Information (EuropePMC)
Title Systematic evaluation of narrow-sense validity of polygenic risk score for prostate cancer in a Chinese prostate biopsy cohort.
PubMed ID 36840471(Europe PMC)
doi 10.1111/cge.14315
Publication Date March 6, 2023
Journal Clin Genet
Author(s) Wu Y, Ruan X, Gao P, Da H, Fang Z, Xu D, Jiang H, Ding Q, Lin X, Lu D, Na R.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004601
(PRS17_Pca)
 PGP000579 |
Wu Y et al. Clin Genet (2023)
 Prostate cancer prostate carcinoma 17
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004601/ScoringFiles/PGS004601.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020757 PGS004601
(PRS17_Pca)
 PSS011394|
East Asian Ancestry|
2,628 individuals
 PGP000579 |
Wu Y et al. Clin Genet (2023)
 Reported Trait: Prostate cancer in males undergoing prostate biopsy — — p (PRS in cases vs controls): 5.56e-17 — —
PPM020758 PGS004601
(PRS17_Pca)
 PSS011393|
East Asian Ancestry|
2,425 individuals
 PGP000579 |
Wu Y et al. Clin Genet (2023)
 Reported Trait: Primary prostate cancer — — p (PRS in cases vs controls): 3.31e-23 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011393 — —
[
  • 1,417 cases
  • , 1,008 controls
]
,
100.0 % Male samples
 — East Asian
(Chinese)		 — NR —
PSS011394 — —
[
  • 1,137 cases
  • , 1,491 controls
]
,
100.0 % Male samples
 — East Asian
(Chinese)		 — NR —