PGS Publication: PGP000580

Publication Information (EuropePMC)
Title Effect of Diet Quality and Genetic Predisposition on Hemoglobin A1C and Type 2 Diabetes Risk: Gene-Diet Interaction Analysis of 357,419 Individuals.
PubMed ID 34433621(Europe PMC)
doi 10.2337/dc21-1051
Publication Date Aug. 25, 2021
Journal Diabetes Care
Author(s) Zhuang P, Liu X, Li Y, Wan X, Wu Y, Wu F, Zhang Y, Jiao J.
Released in PGS Catalog: Jan. 26, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004602
(PRS424_T2D)
 PGP000580 |
Zhuang P et al. Diabetes Care (2021)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 424
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004602/ScoringFiles/PGS004602.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020759 PGS004602
(PRS424_T2D)
 PSS011395|
European Ancestry|
357,419 individuals
 PGP000580 |
Zhuang P et al. Diabetes Care (2021)
 Reported Trait: Type 2 diabetes HR: 1.54 [1.5, 1.58]
β: 0.431 (0.014)		 — — Age, sex, center, BMI, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, history of hypertension, history of high cholesterol, vitamin supplement use, mineral supplement use, aspirin use, and lipid-lowering medication —
PPM020760 PGS004602
(PRS424_T2D)
 PSS011395|
European Ancestry|
357,419 individuals
 PGP000580 |
Zhuang P et al. Diabetes Care (2021)
 Reported Trait: HbA1c β: 0.544 (0.007) — — Age, sex, center, BMI, education, Townsend deprivation index, household income, smoking, alcohol consumption, physical activity, history of hypertension, history of high cholesterol, vitamin supplement use, mineral supplement use, aspirin use, and lipid-lowering medication —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011395 — Mean = 8.1 years 357,419 individuals — European
(White British)		 — UKB —