PGS Publication: PGP000588

Publication Information (EuropePMC)
Title High Polygenic Risk Is Associated with Earlier Trabeculectomy in Patients with Primary Open-Angle Glaucoma.
PubMed ID 35842105(Europe PMC)
doi 10.1016/j.ogla.2022.06.009
Publication Date July 13, 2022
Journal Ophthalmol Glaucoma
Author(s) Marshall HN, Hollitt GL, Wilckens K, Mullany S, Kuruvilla S, Souzeau E, Landers J, Han X, MacGregor S, Craig JE, Siggs OM.
Released in PGS Catalog: Feb. 20, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000137
(MTAG_glaucoma)
 PGP000066 |
Craig JE et al. Nat Genet (2020)
 Glaucoma glaucoma 2,673
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000137/ScoringFiles/PGS000137.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020780 PGS000137
(MTAG_glaucoma)
 PSS011408|
European Ancestry|
903 individuals
 PGP000588 |
Marshall HN et al. Ophthalmol Glaucoma (2022)
|Ext.		 Reported Trait: Age at first trabeculectomy in individuals with primary open-angle glaucoma β: -1.94 [-3.47, -0.41] — — Sex, family history of glaucoma —
PPM020781 PGS000137
(MTAG_glaucoma)
 PSS011408|
European Ancestry|
903 individuals
 PGP000588 |
Marshall HN et al. Ophthalmol Glaucoma (2022)
|Ext.		 Reported Trait: Requirement for bilateral trabeculectomy in individuals with primary open-angle glaucoma — — Odds ratio (OR, top vs bottom PRS decile): 1.41 [1.06, 1.91] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011408 — — 903 individuals,
42.7 % Male samples
 — European — ANZRAG —