PGS Publication: PGP000605

Publication Information (EuropePMC)
Title Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes.
PubMed ID 37353344(Europe PMC)
doi 10.2337/dc23-0353
Publication Date Aug. 1, 2023
Journal Diabetes Care
Author(s) Deutsch AJ, Schroeder PH, Mandla R, Kang S, Erenler F, Mercader JM, Udler MS, Florez JC, Brenner LN.
Released in PGS Catalog: March 28, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004859
(T2D_PRS_CS)
 PGP000605 |
Deutsch AJ et al. Diabetes Care (2023)
 Type 2 diabetes (T2D) type 2 diabetes mellitus 1,108,235
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004859/ScoringFiles/PGS004859.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021084 PGS004859
(T2D_PRS_CS)
 PSS011513|
Multi-ancestry (including European)|
546 individuals
 PGP000605 |
Deutsch AJ et al. Diabetes Care (2023)
 Reported Trait: Glucocorticoid-induced hyperglycemia OR: 1.44 [1.02, 2.04] AUROC: 0.68 — eGFR, glucocorticoid dose —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011513 Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) —
[
  • 2 cases
  • , 4 controls
]
 — Asian unspecified — MGBB —
PSS011513 Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) —
[
  • 13 cases
  • , 16 controls
]
 — African American or Afro-Caribbean — MGBB —
PSS011513 Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) —
[
  • 182 cases
  • , 296 controls
]
 — European — MGBB —
PSS011513 Manual curation of electronic medical records. Cases had no ICD code for diabetes, received a glucocorticoid dose equivalent to >= 10 mg of prednisone, and had random blood glucose >= 200 mg/dL or fasting blood glucose >= 126 mg/dL (drawn between 4:00 AM and 6:59 AM) —
[
  • 13 cases
  • , 20 controls
]
 — Not reported — MGBB —