PGS Publication: PGP000610

Publication Information (EuropePMC)
Title Association of Polygenic Score With Tumor Molecular Subtypes in Papillary Thyroid Carcinoma.
PubMed ID 37453101(Europe PMC)
doi 10.1210/clinem/dgad407
Publication Date Dec. 1, 2023
Journal J Clin Endocrinol Metab
Author(s) Wang JR, Zafereo ME, Wang W, Joshu C, Ray D.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000630
(PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_MGI_20200608)
 PGP000118 |
Fritsche LG et al. Am J Hum Genet (2020)
 Thyroid cancer thyroid carcinoma 10
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000630/ScoringFiles/PGS000630.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021099 PGS000630
(PRSWEB_PHECODE193_GWAS-Catalog-r2019-05-03-X193_P_5e-08_MGI_20200608)
 PSS011527|
Multi-ancestry (including European)|
359 individuals
 PGP000610 |
Wang JR et al. J Clin Endocrinol Metab (2023)
|Ext.		 Reported Trait: BRAFV600E tumor driver subtype in individuals with papillary thyroid carcinoma OR: 1.51 [1.09, 2.08] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011527 — — 245 individuals — European — TCGA —
PSS011527 — — 30 individuals — Asian unspecified — TCGA —
PSS011527 — — 13 individuals — African American or Afro-Caribbean — TCGA —
PSS011527 — — 71 individuals — Not reported — TCGA —