PGS Publication: PGP000617

Publication Information (EuropePMC)
Title Polygenic risk for type 2 diabetes, lifestyle, metabolic health, and cardiovascular disease: a prospective UK Biobank study.
PubMed ID 35836215(Europe PMC)
doi 10.1186/s12933-022-01560-2
Publication Date July 14, 2022
Journal Cardiovasc Diabetol
Author(s) Yun JS, Jung SH, Shivakumar M, Xiao B, Khera AV, Won HH, Kim D.
Released in PGS Catalog: April 18, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
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Additional Asian Ancestries
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
Scoring File (FTP Link)
PGP000617 |
Yun JS et al. Cardiovasc Diabetol (2022)
Type 2 diabetes (T2D) type 2 diabetes mellitus 6,580,804

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021133 PGS004868
European Ancestry|
345,217 individuals
PGP000617 |
Yun JS et al. Cardiovasc Diabetol (2022)
Reported Trait: Incident cardiovascular disease HR: 1.06 [1.04, 1.07] Hazard ratio (HR, top PRS percentile vs bottom quintile): 1.35 [1.19, 1.53] Age, sex, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011537 Median = 8.9 years
IQR = [8.3, 9.5] years
  • 21,865 cases
  • , 323,352 controls
44.6 % Male samples
Mean = 56.1 years
Sd = 8.0 years
(White British)