Polygenic Score (PGS) ID: PGS004868

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: April 18, 2024
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Score Details

Score Construction
PGS Name T2DPGS
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 6,580,804
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000617
Citation (link to publication) Yun JS et al. Cardiovasc Diabetol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
159,208 individuals (100%)
PGS Evaluation
Greater Middle Eastern: 66.7%
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004773
Europe PMC: 28566273
 159,208 individuals European DIAGRAM

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021133 PSS011537|
European Ancestry|
345,217 individuals
 PGP000617 |
Yun JS et al. Cardiovasc Diabetol (2022)
 Reported Trait: Incident cardiovascular disease HR: 1.06 [1.04, 1.07] — Hazard ratio (HR, top PRS percentile vs bottom quintile): 1.35 [1.19, 1.53] Age, sex, genotyping array, 10 PCs —
PPM022875 PSS012080|
Greater Middle Eastern Ancestry|
4,534 individuals
 PGP000753 |
Aliyu U et al. Diabetes Obes Metab (2025)
|Ext.		 Reported Trait: Prediabetes OR: 1.155 [1.081, 1.235] AUROC: 0.644 [0.628, 0.66] R²: 0.081 sex, baseline age, BMI, PCs1-10 —
PPM022957 PSS012081|
Greater Middle Eastern Ancestry|
2,143 individuals
 PGP000753 |
Aliyu U et al. Diabetes Obes Metab (2025)
|Ext.		 Reported Trait: Incident T2D in prediabetics HR: 1.397 [1.195, 1.633] AUROC: 0.755 [0.72, 0.79] — sex, baseline age, BMI, PCs1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012080 age-matched cohort —
[
  • 2,267 cases
  • , 2,267 controls
]
 — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —
PSS012081 — Median = 6.0 years
[
  • 199 cases
  • , 1,944 controls
]
,
54.22 % Male samples
 — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —
PSS011537 — Median = 8.9 years
IQR = [8.3, 9.5] years
[
  • 21,865 cases
  • , 323,352 controls
]
,
44.6 % Male samples
 Mean = 56.1 years
Sd = 8.0 years		 European
(White British)		 — UKB —