PGS Publication: PGP000632

Publication Information (EuropePMC)
Title Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease.
PubMed ID 37536150(Europe PMC)
doi 10.1016/j.atherosclerosis.2023.117194
Publication Date July 26, 2023
Journal Atherosclerosis
Author(s) Aday AW, Bagheri M, Vaitinadin NS, Mosley JD, Wang TJ.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000013
(GPS_CAD)
 PGP000006 |
Khera AV et al. Nat Genet (2018)
 Coronary artery disease coronary artery disease 6,630,150
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021334 PGS000013
(GPS_CAD)
 PSS011689|
European Ancestry|
5,453 individuals
 PGP000632 |
Aday AW et al. Atherosclerosis (2023)
|Ext.		 Reported Trait: Incident myocardial infarction or fatal coronary event HR: 1.37 [1.26, 1.49] C-index: 0.74 [0.71, 0.76] — Age, sex, 5 PCs, pooled cohort equations, high-sensitivity C-reactive protein —
PPM021333 PGS000013
(GPS_CAD)
 PSS011690|
European Ancestry|
2,017 individuals
 PGP000632 |
Aday AW et al. Atherosclerosis (2023)
|Ext.		 Reported Trait: Incident myocardial infarction or fatal coronary event HR: 1.38 [1.16, 1.63] C-index: 0.74 [0.69, 0.77] — Age, sex, 5 PCs, pooled cohort equations, high-sensitivity C-reactive protein —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011689 — Mean = 14.2 years
[
  • 565 cases
  • , 4,888 controls
]
,
42.3 % Male samples
 Mean = 63.0 years
Sd = 5.7 years		 European — ARIC —
PSS011690 — Mean = 18.5 years
[
  • 153 cases
  • , 1,864 controls
]
,
44.2 % Male samples
 Mean = 56.7 years
Sd = 9.2 years		 European — FOS —