PGS Publication: PGP000633

Publication Information (EuropePMC)
Title Integrated proteomics and genomics analysis of paradoxical eczema in psoriasis patients treated with biologics.
PubMed ID 37536512(Europe PMC)
doi 10.1016/j.jaci.2023.07.011
Publication Date Aug. 1, 2023
Journal J Allergy Clin Immunol
Author(s) Al-Janabi A, Martin P, Khan AR, Foulkes AC, Smith CH, Griffiths CEM, Morris AP, Eyre S, Warren RB, BSTOP Study Group and the BADBIR Study Group.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004903
(PRS_ALL)
 PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
 Atopic dermatitis atopic eczema 38
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004903/ScoringFiles/PGS004903.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021335 PGS004903
(PRS_ALL)
 PSS011691|
European Ancestry|
3,212 individuals
 PGP000633 |
Al-Janabi A et al. J Allergy Clin Immunol (2023)
 Reported Trait: Paradoxical eczema in individuals with psoriasis — — Coefficient: 4.77 [0.58, 8.96]
p: 0.026		 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011691 — —
[
  • 88 cases
  • , 3,124 controls
]
 — European — BSTOP —