PGS Publication: PGP000636

Publication Information (EuropePMC)
Title Association between antibiotic use during early life and early-onset colorectal cancer risk overall and according to polygenic risk and FUT2 genotypes.
PubMed ID 37504220(Europe PMC)
doi 10.1002/ijc.34648
Publication Date July 28, 2023
Journal Int J Cancer
Author(s) Jiang F, Boakye D, Sun J, Wang L, Yu L, Zhou X, Zhao J, Bian Z, Song P, He Y, Zhu Y, Chen J, Yuan S, Song M, Larsson SC, Giovannucci EL, Theodoratou E, Ding K, Li X.
Released in PGS Catalog: May 22, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS004904
(PRS127_CRC)
 PGP000636 |
Jiang F et al. Int J Cancer (2023)
 Colorectal cancer colorectal carcinoma 127
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004904/ScoringFiles/PGS004904.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM021341 PGS004904
(PRS127_CRC)
 PSS011697|
European Ancestry|
113,256 individuals
 PGP000636 |
Jiang F et al. Int J Cancer (2023)
 Reported Trait: Incident and prevelant early-onset colorectal cancer OR: 2.29 [1.98, 2.64] — — Age, sex, education, family history, type 1 diabetes, 5 PCs —
PPM021342 PGS004904
(PRS127_CRC)
 PSS011697|
European Ancestry|
113,256 individuals
 PGP000636 |
Jiang F et al. Int J Cancer (2023)
 Reported Trait: Incident early-onset colorectal cancer OR: 2.51 [1.77, 3.56] — — Age, sex, education, family history, type 1 diabetes, 5 PCs —
PPM021343 PGS004904
(PRS127_CRC)
 PSS011697|
European Ancestry|
113,256 individuals
 PGP000636 |
Jiang F et al. Int J Cancer (2023)
 Reported Trait: Incident and prevelant early-onset colorectal adenoma OR: 1.59 [1.48, 1.71] — — Age, sex, education, family history, type 1 diabetes, 5 PCs —
PPM021344 PGS004904
(PRS127_CRC)
 PSS011697|
European Ancestry|
113,256 individuals
 PGP000636 |
Jiang F et al. Int J Cancer (2023)
 Reported Trait: Incident early-onset colorectal adenoma OR: 1.57 [1.39, 1.77] — — Age, sex, education, family history, type 1 diabetes, 5 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011697 — — 113,256 individuals — European — UKB —