Publication Information (EuropePMC) | |
Title | Genetic determinants of thyroid function in children. |
PubMed ID | 37530217(Europe PMC) |
doi | 10.1093/ejendo/lvad086 |
Publication Date | Aug. 1, 2023 |
Journal | Eur J Endocrinol |
Author(s) | Mulder TA, Campbell PJ, Taylor PN, Peeters RP, Wilson SG, Medici M, Dayan C, Jaddoe VVW, Walsh JP, Martin NG, Tiemeier H, Korevaar TIM. |
Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS004907 (PRS31_FT4) |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Free thyroxine concentration | thyroxine measurement | 31 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004907/ScoringFiles/PGS004907.txt.gz |
PGS004906 (PRS60_TSH) |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Thyroid stimulating hormone concentration | thyroid stimulating hormone measurement | 60 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004906/ScoringFiles/PGS004906.txt.gz |
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM021356 | PGS004906 (PRS60_TSH) |
PSS011701| European Ancestry| 7,231 individuals |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Reported Trait: Thyroid stimulating hormone concentration | β: 0.16 (0.01) | — | — | — | — |
PPM021357 | PGS004906 (PRS60_TSH) |
PSS011701| European Ancestry| 7,231 individuals |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Reported Trait: Free thyroxine (FT4) concentration | β: -0.04 (0.01) | — | — | — | — |
PPM021358 | PGS004907 (PRS31_FT4) |
PSS011701| European Ancestry| 7,231 individuals |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Reported Trait: Free thyroxine (FT4) concentration | β: 0.12 (0.01) | — | — | — | — |
PPM021359 | PGS004907 (PRS31_FT4) |
PSS011701| European Ancestry| 7,231 individuals |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Reported Trait: Thyroid stimulating hormone concentration | β: 0.03 (0.01) | — | — | — | — |
PPM021360 | PGS004907 (PRS31_FT4) |
PSS011701| European Ancestry| 7,231 individuals |
PGP000639 | Mulder TA et al. Eur J Endocrinol (2023) |
Reported Trait: Free tri-iodothyronine (FT3) concentration | β: -0.04 (0.01) | — | — | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS011701 | — | — | 1,680 individuals, 49.3 % Male samples |
Median = 12.1 years 95% Range = [12.0, 12.5] years |
European | — | BLTS | — |
PSS011701 | — | — | 2,169 individuals, 50.8 % Male samples |
Median = 6.0 years 95% Range = [5.7, 7.5] years |
European | — | Generation_R | — |
PSS011701 | — | — | 3,382 individuals, 52.0 % Male samples |
Median = 7.5 years 95% Range = [7.3, 8.9] years |
European | — | ALSPAC | — |