PGS Publication: PGP000686

Publication Information (EuropePMC)
Title Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss.
PubMed ID 37494631(Europe PMC)
doi 10.2337/db23-0131
Publication Date Oct. 1, 2023
Journal Diabetes
Author(s) Christiansen MR, Kilpeläinen TO, McCaffery JM.
Released in PGS Catalog: Oct. 29, 2024

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
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Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005095
(WHRadjBMI_GRS)
 PGP000686 |
Christiansen MR et al. Diabetes (2023)
 WHR adjusted for BMI BMI-adjusted waist-hip ratio 481
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005095/ScoringFiles/PGS005095.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022186 PGS005095
(WHRadjBMI_GRS)
 PSS011834|
Multi-ancestry (including European)|
1,415 individuals
 PGP000686 |
Christiansen MR et al. Diabetes (2023)
 Reported Trait: Waist circumference change following weight loss (year 1 to year 2) β: 0.033 (0.01) — — Intervention arm, sex, baseline age, 4 PCs, baseline weight, baseline height, baseline WC, year-1 weight and waist circumference, year-2 weight —
PPM022187 PGS005095
(WHRadjBMI_GRS)
 PSS011834|
Multi-ancestry (including European)|
1,415 individuals
 PGP000686 |
Christiansen MR et al. Diabetes (2023)
 Reported Trait: Waist circumference change following weight loss (year 1 to year 4) β: 0.026 (0.01) — — Intervention arm, sex, baseline age, 4 PCs, baseline weight, baseline height, baseline WC, year-1 weight and waist circumference, year-4 weight —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011834 — — 952 individuals — European — Look AHEAD —
PSS011834 — — 187 individuals — African unspecified — Look AHEAD —
PSS011834 — — 233 individuals — Hispanic or Latin American — Look AHEAD —
PSS011834 — — 43 individuals — Not reported — Look AHEAD —