PGS Publication: PGP000756

Publication Information (EuropePMC)
Title Clinical Application of Polygenic Risk Score in IgA Nephropathy.
PubMed ID 38884057(Europe PMC)
doi 10.1007/s43657-023-00138-6
Publication Date March 21, 2024
Journal Phenomics
Author(s) Xu L, Gan T, Chen P, Liu Y, Qu S, Shi S, Liu L, Zhou X, Lv J, Zhang H.
Released in PGS Catalog: Aug. 6, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005282
(GRS15_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IGA glomerulonephritis 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005282/ScoringFiles/PGS005282.txt.gz
PGS005283
(GRS21_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IGA glomerulonephritis 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005283/ScoringFiles/PGS005283.txt.gz
PGS005284
(GRS55_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IGA glomerulonephritis 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005284/ScoringFiles/PGS005284.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022989 PGS005282
(GRS15_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.36 [1.3, 1.42] AUROC: 0.59 — — —
PPM022990 PGS005283
(GRS21_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.62 [1.55, 1.69] AUROC: 0.63 — — —
PPM022991 PGS005284
(GRS55_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.62 [1.55, 1.69] AUROC: 0.63 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012087 — —
[
  • 3,365 cases
  • , 8,842 controls
]
 — East Asian
(Chinese)		 — NR PKU-IgAN Cohort