PGS Publication: PGP000765

Publication Information (EuropePMC)
Title Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years.
PubMed ID 38587023(Europe PMC)
doi 10.1002/mdc3.14044
Publication Date April 8, 2024
Journal Mov Disord Clin Pract
Author(s) Gandhi SE, Zerenner T, Nodehi A, Lawton MA, Marshall V, Al-Hajraf F, Grosset KA, Morris HR, Hu MT, Ben-Shlomo Y, Grosset DG.
Released in PGS Catalog: Oct. 6, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000902
(PRS90_PD)
 PGP000235 |
Nalls MA et al. Lancet Neurol (2019)
 Parkinson's disease Parkinson disease 90
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000902/ScoringFiles/PGS000902.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023054 PGS000902
(PRS90_PD)
 PSS012105|
Ancestry Not Reported|
3,453 individuals
 PGP000765 |
Gandhi SE et al. Mov Disord Clin Pract (2024)
|Ext.		 Reported Trait: dyskinesia (2-4 years after diagnosis) OR: 1.34 [1.036, 1.737] — — Age at diagnosis, Female gender, Interpolated BMI, Education > 12 years, MDS-UPDRS part 1, Depression (score > 0), Anxiety (score > 0), MDS-UPDRS part 2, MDS-UPDRS part 3, MDS-UPDRS part 3 tremor subscore, HY3 plus, MDS-UPDRS part 3 progression, Total LEDD —
PPM023055 PGS000902
(PRS90_PD)
 PSS012105|
Ancestry Not Reported|
3,453 individuals
 PGP000765 |
Gandhi SE et al. Mov Disord Clin Pract (2024)
|Ext.		 Reported Trait: dyskinesia (8=10 years after diagnosis) OR: 1.401 [1.024, 1.93] — — Age at diagnosis, Female gender, Interpolated BMI, Education > 12 years, MDS-UPDRS part 1, Depression (score > 0), Anxiety (score > 0), MDS-UPDRS part 2, MDS-UPDRS part 3, MDS-UPDRS part 3 tremor subscore, HY3 plus, MDS-UPDRS part 3 progression, Total LEDD —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012105 — — 3,453 individuals,
64.7 % Male samples
 Mean = 65.6 years
Sd = 9.6 years		 Not reported — OD, PPMI, TP —