PGS Publication: PGP000770

Publication Information (EuropePMC)
Title Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities.
PubMed ID 40999017(Europe PMC)
doi 10.1038/s43856-025-01107-y
Publication Date Sept. 25, 2025
Journal Commun Med (Lond)
Author(s) Hrytsenko Y, Spitzer BW, Wang H, Bertisch SM, Taylor KD, Garcia-Bedoya O, Ramos AR, Daviglus ML, Gallo LC, Isasi CR, Cai J, Qi Q, Alcántara C, Redline S, Sofer T.
Released in PGS Catalog: Nov. 10, 2025

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005328
(T2D_PRS_EAS)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 570,349
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005328/ScoringFiles/PGS005328.txt.gz
PGS005329
(T2D_PRS_EUR)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 1,112,468
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005329/ScoringFiles/PGS005329.txt.gz
PGS005330
(T2D_PRS_SAS)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 642,349
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005330/ScoringFiles/PGS005330.txt.gz
PGS005324
(T2D_PRS_weighted)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 1,279,733
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005324/ScoringFiles/PGS005324.txt.gz
PGS005325
(T2D_PRS_unweighted)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 1,279,733
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005325/ScoringFiles/PGS005325.txt.gz
PGS005326
(T2D_PRS_AFR)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 1,214,634
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005326/ScoringFiles/PGS005326.txt.gz
PGS005327
(T2D_PRS_AMR)
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Type 2 Diabetes Mellitus type 2 diabetes mellitus 972,776
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005327/ScoringFiles/PGS005327.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023076 PGS005324
(T2D_PRS_weighted)
 PSS012112|
Hispanic or Latin American Ancestry|
12,309 individuals
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Reported Trait: Incident Type 2 Diabetes Mellitus OR: 2.77 [2.44, 3.13] — — age, sex, BMI, study center, and genetic PCs Constructed as an unweighted average of ancestry-specific PRSs (AFR, AMR, EAS, EUR, SAS) derived using PRS-CSx; no ancestry-proportion weighting applied.
PPM023075 PGS005325
(T2D_PRS_unweighted)
 PSS012112|
Hispanic or Latin American Ancestry|
12,309 individuals
 PGP000770 |
Hrytsenko Y et al. Commun Med (Lond) (2025)
 Reported Trait: Incident Type 2 Diabetes Mellitus OR: 3.13 [2.75, 3.56] — — age, sex, BMI, study center, and genetic PCs Constructed as a weighted combination of ancestry-specific PRSs (AFR, AMR, EAS, EUR, SAS) derived using PRS-CSx; weights correspond to individual ancestry proportions estimated in the HCHS/SOL cohort.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012112 — —
[
  • 2,405 cases
  • , 9,904 controls
]
 — Hispanic or Latin American
(Cuban, Central American, Dominican, Mexican, Puerto Rican, and South American)		 — HCHS-SOL —