PGS Publication: PGP000771

Publication Information (EuropePMC)
Title Performance of different polygenic risk scores for breast cancer risk prediction: in-depth evaluations across large UK and Australian cohorts.
PubMed ID 41526671(Europe PMC)
doi 10.1038/s41431-025-02003-8
Publication Date Jan. 13, 2026
Journal Eur J Hum Genet
Author(s) Tanha HM, Law MH, Ingold N, Olsen CM, Pandeya N, Milne RL, MacInnis RJ, Whiteman DC, Cust AE, Steinberg J.
Released in PGS Catalog: Feb. 26, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005347
(PRS-CS)
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Breast carcinoma breast carcinoma 941,932
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005347/ScoringFiles/PGS005347.txt.gz
PGS005345
(SCT)
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Breast carcinoma breast carcinoma 435,538
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005345/ScoringFiles/PGS005345.txt.gz
PGS005348
(SBayesR)
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Breast carcinoma breast carcinoma 789,305
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005348/ScoringFiles/PGS005348.txt.gz
PGS005346
(LDpred2)
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Breast carcinoma breast carcinoma 961,355
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005346/ScoringFiles/PGS005346.txt.gz
PGS005349
(SBayesRC)
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Breast carcinoma breast carcinoma 5,387,266
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005349/ScoringFiles/PGS005349.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM023137 PGS005345
(SCT)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.641 [0.632, 0.651] — - —
PPM023138 PGS005346
(LDpred2)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.663 [0.654, 0.673] — - —
PPM023139 PGS005347
(PRS-CS)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.658 [0.649, 0.668] — - —
PPM023140 PGS005348
(SBayesR)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.663 [0.654, 0.673] — - —
PPM023141 PGS005349
(SBayesRC)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.639 [0.63, 0.649] — - —
PPM023142 PGS005345
(SCT)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.637 [0.598, 0.677] — - —
PPM023143 PGS005346
(LDpred2)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.658 [0.619, 0.697] — - —
PPM023144 PGS005347
(PRS-CS)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.662 [0.622, 0.701] — - —
PPM023145 PGS005348
(SBayesR)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.65 [0.611, 0.69] — - —
PPM023146 PGS005349
(SBayesRC)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.647 [0.607, 0.686] — - —
PPM023147 PGS005345
(SCT)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.658 [0.619, 0.697] — - —
PPM023148 PGS005346
(LDpred2)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.683 [0.644, 0.722] — - —
PPM023149 PGS005347
(PRS-CS)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.673 [0.634, 0.712] — - —
PPM023151 PGS005349
(SBayesRC)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.727 [0.692, 0.762] — - —
PPM023152 PGS005345
(SCT)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.626 [0.517, 0.735] — - —
PPM023153 PGS005346
(LDpred2)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.592 [0.479, 0.705] — - —
PPM023154 PGS005347
(PRS-CS)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.598 [0.483, 0.713] — - —
PPM023155 PGS005348
(SBayesR)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.607 [0.501, 0.713] — - —
PPM023156 PGS005349
(SBayesRC)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.605 [0.483, 0.727] — - —
PPM023157 PGS005345
(SCT)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.659 [0.585, 0.732] — - —
PPM023159 PGS005347
(PRS-CS)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.678 [0.597, 0.76] — - —
PPM023160 PGS005348
(SBayesR)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.657 [0.575, 0.74] — - —
PPM023161 PGS005349
(SBayesRC)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.693 [0.614, 0.773] — - —
PPM023163 PGS005346
(LDpred2)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.667 [0.657, 0.676] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023164 PGS005347
(PRS-CS)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.662 [0.652, 0.672] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023165 PGS005348
(SBayesR)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.667 [0.657, 0.676] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023166 PGS005349
(SBayesRC)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.644 [0.634, 0.654] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023167 PGS005345
(SCT)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.638 [0.598, 0.679] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023168 PGS005346
(LDpred2)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.656 [0.616, 0.696] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023169 PGS005347
(PRS-CS)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.656 [0.616, 0.696] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023170 PGS005348
(SBayesR)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.646 [0.607, 0.685] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023171 PGS005349
(SBayesRC)
 PSS012138|
European Ancestry|
8,291 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.645 [0.605, 0.685] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023172 PGS005345
(SCT)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.647 [0.609, 0.686] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023174 PGS005347
(PRS-CS)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.663 [0.625, 0.701] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023175 PGS005348
(SBayesR)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.66 [0.621, 0.699] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023176 PGS005349
(SBayesRC)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.713 [0.678, 0.748] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023177 PGS005345
(SCT)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.621 [0.526, 0.716] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023178 PGS005346
(LDpred2)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.59 [0.488, 0.691] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023179 PGS005347
(PRS-CS)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.592 [0.489, 0.695] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023180 PGS005348
(SBayesR)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.611 [0.514, 0.707] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023181 PGS005349
(SBayesRC)
 PSS012139|
African Ancestry|
4,427 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.585 [0.485, 0.685] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023182 PGS005345
(SCT)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.635 [0.559, 0.712] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023183 PGS005346
(LDpred2)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.642 [0.558, 0.727] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023184 PGS005347
(PRS-CS)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.653 [0.569, 0.737] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023185 PGS005348
(SBayesR)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.639 [0.556, 0.723] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023150 PGS005348
(SBayesR)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.666 [0.627, 0.706] — - —
PPM023158 PGS005346
(LDpred2)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.67 [0.59, 0.75] — - —
PPM023162 PGS005345
(SCT)
 PSS012140|
European Ancestry|
212,360 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.645 [0.635, 0.655] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023173 PGS005346
(LDpred2)
 PSS012137|
European Ancestry|
2,654 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.676 [0.636, 0.715] — Age-specific absolute risk adjusted by PGS relative risk —
PPM023186 PGS005349
(SBayesRC)
 PSS012141|
South Asian Ancestry|
4,435 individuals
 PGP000771 |
Tanha HM et al. Eur J Hum Genet (2026)
 Reported Trait: Breast Carcinoma — AUROC: 0.647 [0.564, 0.731] — Age-specific absolute risk adjusted by PGS relative risk —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012137 Linked cancer registry records were used to identify females diagnosed with invasive breast cancer (ICD-10 code: C50; ICD-9 code: 174) within five years of prediction baseline. —
[
  • 194 cases
  • , 2,460 controls
]
,
0.0 % Male samples
 European PC1-PC4 values ±3s.d. from the 1000G European cluster MCCS MCCS had a case/sub-cohort design, leading to a higher proportion of cases
PSS012138 Linked cancer registry records were used to identify females diagnosed with invasive breast cancer (ICD-10 code: C50; ICD-9 code: 174) within five years of prediction baseline. —
[
  • 176 cases
  • , 8,115 controls
]
,
0.0 % Male samples
 European PC1-PC4 values ±3s.d. from the 1000G European cluster QSKIN —
PSS012139 Linked cancer registry records were used to identify females diagnosed with invasive breast cancer (ICD-10 code: C50; ICD-9 code: 174) within five years of prediction baseline. —
[
  • 27 cases
  • , 4,400 controls
]
,
0.0 % Male samples
 African American or Afro-Caribbean AFR individuals were identified by PC1-PC4 from 1000G and k-means clustering. UKB —
PSS012140 Linked cancer registry records were used to identify females diagnosed with invasive breast cancer (ICD-10 code: C50; ICD-9 code: 174) within five years of prediction baseline. —
[
  • 3,083 cases
  • , 209,277 controls
]
,
0.0 % Male samples
 European EUR individuals were identified by PC1-PC4 from 1000G and k-means clustering. UKB —
PSS012141 Linked cancer registry records were used to identify females diagnosed with invasive breast cancer (ICD-10 code: C50; ICD-9 code: 174) within five years of prediction baseline. —
[
  • 43 cases
  • , 4,392 controls
]
,
0.0 % Male samples
 South Asian SAS individuals were identified by PC1-PC4 from 1000G and k-means clustering. UKB —