PGS Publication: PGP000785

Publication Information (EuropePMC)
Title Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores.
PubMed ID 41865802(Europe PMC)
doi 10.1016/j.jaci.2026.03.008
Publication Date March 20, 2026
Journal J Allergy Clin Immunol
Author(s) Trimarchi MP, Namjou-Khales B, Ben-Baruch Morgenstern N, Rochman M, Chen X, Osswald GA, Besse JA, Shook MS, Caldwell JM, Lape M, Shoda T, Weirauch MT, Ruffner MA, Constantine GM, Martin LJ, Kottyan LC, Rothenberg ME, Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators.
Released in PGS Catalog: April 13, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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PGS Developed By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012513
(eoe)
 PGP000785 |
Trimarchi MP et al. J Allergy Clin Immunol (2026)
 Eosinophilic esophagitis (EOE) eosinophilic esophagitis 1,039,900
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012513/ScoringFiles/PGS012513.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030557 PGS012513
(eoe)
 PSS012193|
European Ancestry|
3,837 individuals
 PGP000785 |
Trimarchi MP et al. J Allergy Clin Immunol (2026)
 Reported Trait: EoE OR: 1.71 [1.52, 1.92] AUROC: 0.8 [0.78, 0.81] R²: 0.2 age, sex, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012193 — —
[
  • 724 cases
  • , 3,113 controls
]
 — European — NR —