PGS Publication: PGP000806

Publication Information (EuropePMC)
Title Evaluating interactions of polygenic risk scores and NAT2 genotypes with tobacco smoking in bladder cancer risk.
PubMed ID 37728483(Europe PMC)
doi 10.1002/ijc.34736
Publication Date Sept. 20, 2023
Journal Int J Cancer
Author(s) Pradhan P, Jia G, Khankari NK, Zheng W, Zheng W.
Released in PGS Catalog: May 7, 2026

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS012553
(PRS24_BC)
 PGP000796 |
Koutros S et al. Eur Urol (2023)
 Bladder cancer urinary bladder carcinoma 24
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012553/ScoringFiles/PGS012553.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030707 PGS012553
(PRS24_BC)
 PSS012259|
European Ancestry|
390,678 individuals
 PGP000806 |
Pradhan P et al. Int J Cancer (2023)
|Ext.		 Reported Trait: Bladder cancer — — Hazard ratio (HR, high vs low PGS tertile): 1.74 [1.46, 2.08] Sex, education 23 of 24 variants analysed (rs36209093 excluded)
PPM030708 PGS012553
(PRS24_BC)
 PSS012259|
European Ancestry|
390,678 individuals
 PGP000806 |
Pradhan P et al. Int J Cancer (2023)
|Ext.		 Reported Trait: Bladder cancer — — Hazard ratio (HR, current smoker and PGS in highest tertile vs never smoker and PGS in lowest tertile): 6.45 [4.51, 9.24] Sex, education, income, genotype array, 5 PCs 23 of 24 variants analysed (rs36209093 excluded)

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012259 — —
[
  • 769 cases
  • , 389,909 controls
]
,
47.0 % Male samples
 Mean = 56.6 years European — UKB —