PGS Publication: PGP000815

Publication Information (EuropePMC)
Title Exploring ethnic and racial differences in intraocular pressure and glaucoma: The Canadian Longitudinal Study on aging.
PubMed ID 38586381(Europe PMC)
doi 10.1016/j.heliyon.2024.e28611
Publication Date March 26, 2024
Journal Heliyon
Author(s) Grant A, Roy-Gagnon MH, Bastasic J, Talekar A, Miller G, Li G, Freeman EE.
Released in PGS Catalog: June 17, 2026

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000137
(MTAG_glaucoma)
 PGP000066 |
Craig JE et al. Nat Genet (2020)
 Glaucoma glaucoma 2,673
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000137/ScoringFiles/PGS000137.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM030737 PGS000137
(MTAG_glaucoma)
 PSS012272|
Multi-ancestry (including European)|
25,394 individuals
 PGP000815 |
Grant A et al. Heliyon (2024)
|Ext.		 Reported Trait: IOP β: 0.81 [0.74, 0.87] — — age, sex, education, income, smoking, alcohol intake, BMI, diabetes, high blood pressure, eye care utilization, and province —
PPM030738 PGS000137
(MTAG_glaucoma)
 PSS012272|
Multi-ancestry (including European)|
25,394 individuals
 PGP000815 |
Grant A et al. Heliyon (2024)
|Ext.		 Reported Trait: glaucoma OR: 1.56 [1.42, 1.71] — — age, sex, education, income, smoking, alcohol intake, BMI, diabetes, high blood pressure, and province —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012272 — — 24,043 individuals — European — CLSA —
PSS012272 — — 160 individuals — African American or Afro-Caribbean — CLSA —
PSS012272 — — 205 individuals — East Asian
(Chinese, Japanese and Korean)		 — CLSA —
PSS012272 — — 80 individuals — South East Asian
(Southeast Asian and Filipino)		 — CLSA —
PSS012272 — — 209 individuals — South East Asian — CLSA —
PSS012272 — — 99 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Arab and West Asian)		 — CLSA —
PSS012272 — — 82 individuals — Hispanic or Latin American
(Latin American)		 — CLSA —
PSS012272 — — 516 individuals — Not reported — CLSA —